geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Biogenic 4-hydroxy-2-nonenal activates transcription factor AP-1 but not NF-kappa B in cells of the macrophage lineage


, : Biogenic 4-hydroxy-2-nonenal activates transcription factor AP-1 but not NF-kappa B in cells of the macrophage lineage. Biofactors 6(2): 173-179

A large spectrum of pro-oxidant agents, including molecules with lipoperoxidative effect, can modulate gene expression through modification of the DNA binding activity of the transcription factors activator protein 1 (AP-1) and nuclear factor kappa B (NF-kappa B). In this study the effect on these redox-sensitive factors by 4-hydroxy-2-nonenal (HNE), a major aldehydic product of lipid peroxidation, was examined in two cell lines of the macrophage type. Incubation in the presence of microM concentrations of the aldehyde led to a rapid increase of AP-1 binding with a transient maximum 30 min from HNE addition to the culture medium in both cell lines. On the contrary, HNE did not stimulate nuclear translocation of NF-kappa B. The diverging effect of HNE on the two transcription factors is likely related to the demonstrated differential activation pathway of AP-1 and NF-kappa B in macrophages. The HNE-induced activation of AP-1 suggests the aldehyde's involvement in the regulatory mechanisms of cell proliferation and differentiation.

US$29.90

PMID: 9259999


Other references

Avramov, M., 1960: Results of the treatment of chronic hyperthyroidism with methylmercaptoimidazole preparations. Suvremenna Meditsina 11(10): 59-64

Roach, J.C.; Boysen, C.; Wang, K.; Hood, L., 1995: Pairwise end sequencing: a unified approach to genomic mapping and sequencing. Strategies for large-scale genomic DNA sequencing currently require physical mapping, followed by detailed mapping, and finally sequencing. The level of mapping detail determines the amount of effort, or sequence redundancy, required to finish a p...

Maione, M.; Mazzi, C.; Nannicini, P.; Fabbrini, G.P., 1984: Continuous electroencephalographic registration with the Berg-Fourier instrument: enflurane and clinical anesthesia. Minerva Anestesiologica 50(5): 177-181

Martin, J.A.; Mitchell, C.J.; Klingelhutz, A.J.; Buckwalter, J.A., 2002: Effects of telomerase and viral oncogene expression on the in vitro growth of human chondrocytes. Senescent chondrocytes accumulate with aging in articular cartilage, a process that interferes with cartilage homeostasis and increases the risk of cartilage degeneration. We showed previously that chondrocyte telomere length declines with donor a...

Chapman, W.G.; Ramshaw, I.A.; Crick, J., 1973: Inactivated rabies vaccine produced from the flury lep strain of virus grown in baby hamster kidney bhk 21 suspension cells. Applied Microbiology 26(6): 858-862

Hirsch, I.B.; Marker, J.C.; Smith, L.J.; Spina, R.J.; Parvin, C.A.; Holloszy, J.O.; Cryer, P.E., 1991: Insulin and glucagon in prevention of hypoglycemia during exercise in humans. To assess the roles of decrements in insulin and increments in glucagon in the prevention of hypoglycemia during moderate exercise (approximately 60% peak O2 consumption for 60 min), normal young men were studied during somatostatin infusions with...

Harvey, B.J.A.; Kiss, F.; Carson, J.M., 2009: Geophysical series, NTS 86 F/9 and 86 F/10, airborne geophysical survey of the northern Great Bear magmatic zone, Northwest Territories--Serie des cartes geophysiques, SNRC 86 F/9 et 86 F/10, leve; geophysique aeroporte de la partie nord de la zone magmatique du Grand lac de lOurs, Territoires du Nord-Ouest. Geological Survey of Canada: 10 sheets

Gao, C.; Ye, W.; Li, L.; Zhang, T.; Ren, C.; Cheng, L.; Yan, J., 2009: Investigation on the structure of ventricular mass using magnetic resonance diffusion tensor imaging. The 3-dimensional arrangement of the ventricular mass remains controversial. In this study, we used magnetic resonance diffusion tensor imaging (MRDTI) in an attempt to determine whether the ventricular mass is arranged in the form of a helical ve...

Asher, W.J.; Bovee, K.C.; Vogler, T.C.; Hamilton, R.W.; Holtzapple, P.G., 1979: Liquid membrane capsules administered to the gastro intestinal tracts of dogs for removal of urea from the blood. Clinical Nephrology 11(2): 92-96

Steck, S.; Samet, J.; Devlin, R.; Kohlmeier, L., 1997: Plasma carotenoid responsiveness to ozone exposure in humans. FASEB Journal 11(3): A586