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Brain distribution of UCP2 mRNA: in situ hybridization histochemistry studies


, : Brain distribution of UCP2 mRNA: in situ hybridization histochemistry studies. International Journal of Obesity and Related Metabolic Disorders 23 Suppl 6: S53-S55

Uncoupling protein-2 (UCP2) is expressed in large amounts in several tissues. In the mouse brain, in situ hybridization studies have revealed an abundant expression of UCP2 mRNA in the ventral septal region, the hypothalamus, the hindbrain (medulla), the ventricular regions and the cerebellum. In the hypothalamus, a very highly intense hybridization signal is apparent in the suprachiasmatic nucleus, in the medial parvicellular and magnocellular lateral parts of the paraventricular hypothalamic nucleus, and in the arcuate nucleus. In the brainstem, UCP2 is found to be strongly expressed in the dorsal motor nucleus of the vagus nerve. The expression of UCP2 mRNA is also clearly noticeable in the choroid plexuses and in the cerebellum. The expression of UCP2 mRNA in specific regions of the brain as well as its presence in neurons with a known chemical identity suggest that UCP2 mRNA is expressed in neurons. It is as yet premature to conclude about a specific function of UCP2 in the brain. The brain distribution pattern of its transcript suggests that this mitochondrial protein could be part of neuronal circuitries involved in the control of neuroendocrine functions and autonomic responses. Assuming that the UCP2 mRNA encodes a functional uncoupling protein, it can be argued that UCP2 contributes to the metabolic rate and thermoregulation of the neuronal structures to which it is associated. In addition, by elevating oxygen consumption in the brain, UCP2 could in specific regions control the production of reactive oxygen species and thereby influence the process of neural degeneration.

US$29.90

PMID: 10454125


Other references

Tomme M.F., 1971: The use of chemical means in animal husbandry. Khimiya v Sel'skom Khozyaistve 9(3): 60-63

Verspyck, E., 2004: Preventing adverse obstetric outcome in women with thrombophilia. Thrombophilia may represent a new risk factor for placental vascular disorders. Thromboprophylaxis with low doses of heparin and aspirin may be discussed in order to reduced adverse obstetric outcomes. No randomized controlled trials are currently...

De-Saint-Blanquat, G.; Vidaillac, G.; Lamboeuf, Y., 1978: Tissue retention and release of disulfiram administered various ways in the rat. Tissue distribution of disulfiram [used in alcohol detoxification] in the rat was studied after a single dose and after repeated daily administration for 1-mo. After the single dose, disulfiram was found in dose-related quantities in the blood, li...

Andrieux, J.R.; Demory, J.L.up; Dupriez, B.; Bilhou Nabera, C.; L.B.usse Kerdiles, M.C.roline; Bauters, F.; Lai, J.L.c; Kerckaert, J.P.erre, 2003: Overexpression of HMGA2 in blood and bone marrow cells from patients with myelofibrosis with myeloid metaplasia. Myelofibrosis with myeloid metaplasia (MMM) is a chronic myeloproliferative disorder characterized by bone marrow fibrosis, extramedullary haematopoiesis and high levels of circulating CD34+ cells. Cytogenetic studies have demonstrated that MMM ar...

Ruddy, T.D.; Gill, J.B.; Finkelstein, D.M.; Strauss, H.W.; McKusick, K.A.; Okada, R.D.; Boucher, C.A., 1987: Myocardial uptake and clearance of thallium-201 in normal subjects: comparison of dipyridamole-induced hyperemia with exercise stress. Thallium-201 uptake and clearance after dipyridamole infusion may differ from that after exercise stress because the hemodynamic effects of these two interventions are different. In this study of normal volunteers, thallium kinetics after dipyrida...

Shakuntala, I.; Giri, S.C.; Yadav, B.P.S.; Kumar, A., 2003: Bacterial isolates from bovine mastitis and sensitivity pattern to different antibiotics. The prevalence of bacteria causing mammary infections in milch cows in the Dairy Unit of ICAR Research Complex for NEH Region, Meghalaya, India, was investigated. A total of 58 milk samples collected from clinical and suspected cases of mastitis c...

Leary, J.F.; Cantarero, L.A., 1998: Applications of high-speed flow cytometry. Cytometry (SUPPL 9): 113-114

Moldenke, Hn, 1979: Additional notes on the genus Lippia. XV. Phytologia 41(3): 145-151

Kretzschmar, C., 1983: Eradication of infection with viruses of infections bovine rhinotracheitis (IBR) and infectious pustulous vulvovaginitis (IPV). 2. Virus latency of vaccination virus strain of Riems IBR. Archiv fur experimentelle Veterinarmedizin7(6): 829-835

Sozinov, A.A.; Poperlya, F.A.; Parfent' ev, M.G., 1972: Genetics of grain-quality characters in winter wheats. These studies have been carried out at the All-Union Institute of Plant Breeding and Genetics since 1961. The grain quality of F1 hybrids was intermediate between the parents, with a tendency toward the inferior parent. Positive transgression for...