geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Calcium polycarbophil in clinical practice. The therapy of constipation


, : Calcium polycarbophil in clinical practice. The therapy of constipation. Minerva Gastroenterologica E Dietologica 39(4): 175-178

The clinical efficacy of polycarbophil calcium was assessed in 57 patients of both sexes aged between 18 and 77 years old affected by chronic non-organic constipation. The multicentre study was performed using a single blind and cross-over protocol for 8 weeks, 4 with placebo and 4 with the drug (2 c.p.s 3 t.i.d). Thirteen patients failed to complete the study, 8 of them for reasons not related to the drug. In comparison to placebo, the drug caused a significant reduction in the consistency of stool and evacuatory force during the first week of stool therapy. Medical judgement was that efficacy was "very good" in 73% and "good" in 18%, whereas the drug was thought to be "non efficacious" in 9% of cases. The statistical analysis of data confirmed the efficacy of the drug. The hematochemical parameters evaluated before, during and after treatment only showed a slight increase in calcemia and calciuria which did not reach statistical significance. The therapeutic efficacy and lack of undesired effects confirm the value of polycarbophyl calcium in the treatment of chronic constipation.

US$29.90

PMID: 8161616


Other references

Cheylan G., 1974: Bio geography of a mediterranean mountain st victoire department of bouches du rhone part 1 ornithological inventory. Alauda 42(1): 57-78

Anighoro, A.; Bajorath, Jürgen., 2016: Three-Dimensional Similarity in Molecular Docking: Prioritizing Ligand Poses on the Basis of Experimental Binding Modes. Molecular docking is the premier approach to structure-based virtual screening. While ligand posing is often successful, compound ranking using force field-based scoring functions remains difficult. Uncertainties associated with scoring often limi...

Elkind, A.H.; Friedman, A.P.; Bachman, A.; Siegelman, S.S.; Sacks, O.W., 1968: Silent retroperitoneal fibrosis associated with methysergide therapy. JAMA 206(5): 1041-1044

Gipe, B., 2000: Physician refugees from managed care. The rise and fall of a practice management fiasco. Cost & Quality 5(3): 18-20

Wessels, A.; Phelps, A.; Riley, B.; Mccoy, G.; Maharaj, C.; Eid, H.; Perez Pomares, J.M.ria; Sedmerova, M., 2003: In vitro studies on growth factor induced epicardial differentiation. Cell-fate tracing studies have demonstrated that epicardially-derived cells (EPDCs) are multipotential. They can differentiate into a variety of different cell types including coronary endothelial and smooth muscle cells, interstitial fibroblasts,...

Anonymous, 2011: ACR launches dose index registry. Medical imaging facilities can now submit anonymized dose information for all CT exams performed to the Dose Index Registry (DIR) -- allowing them to compare their dose indices to other facilities of similar size or geographic area and to national...

McGuire, W.L.; Clark, G.M., 1983: The prognostic role of progesterone receptors in human breast cancer. Estrogen-receptor protein is known to be an important prognostic factor for patients with breast cancer. The presence of estrogen receptor correlates with response to endocrine therapy in patients with metastatic disease and is associated with pro...

Tian Lifu; Sun Liming; Wang Lifeng; H.H.abin, 1996: The stratum and the environment of the Quaternary in the Xiahuayan region, Hebei. Hebei Dizhi Xueyuan Xuebao = Journal of Hebei College of Geology 19(3-4): 330-337

Tsukamoto, T.; Yuasa, M.; Yamamoto, H.; Kawada, M.; Takeda, A.; Igarashi, H.; Matano, T., 2007: Induction of CD8+ cells able to suppress CCR5-tropic simian immunodeficiency virus SIVmac239 replication by controlled infection of CXCR4-tropic simian-human immunodeficiency virus in vaccinated rhesus macaques. Recent recombinant viral vector-based AIDS vaccine trials inducing cellular immune responses have shown control of CXCR4-tropic simian-human immunodeficiency virus (SHIV) replication but difficulty in containment of pathogenic CCR5-tropic simian...

Bryant, L.D.; Dierdorf, S.F., 1992: Postanesthesia recovery. The care provided in the postanesthesia recovery unit has become much more sophisticated in recent years. We address what type of care should be provided and what equipment is required to provide such care in the present day pediatric postanesthes...