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Cancer vaccines, a critical review--Part I

, : Cancer vaccines, a critical review--Part I. Current Opinion in Investigational Drugs 3(1): 140-149

Cancer vaccines are more properly referred to as 'active specific immunotherapy', and are used to treat cancers rather than to prevent them, at least at present. Vaccines augment already established tumor immunity, are far more specific against the tumor than cytokines, have little or no toxicity, and thus may easily be combined with other types of immunotherapy. They also elicit immunological memory, which may check recurrence of the tumor. Melanoma vaccines have received the most attention thus far. Among the several vaccines in clinical trials are whole cell lysates, such as Melacine, hapten-treated autologous melanoma cells (M-Vax) and irradiated allogeneic cells (CancerVax). Regressions of metastatic nodules have been noted with each preparation. Controlled trials of Melacine indicate prolongation of survival in patients with resected stage IIB disease, particularly those with one or more of the following HLA class I alleles: HLA-A2 or -A28 (-A6802), HLA-B12, -44 or -45, and HLA-C3. A combination of interferon-alpha2b and Melacine appears to enhance the anti-tumor response in advanced (stage IV) disease, and is being tested in a large randomized controlled trial in resected stage III disease. An irradiated autologous colon carcinoma vaccine has improved relapse-free survival in resected stage II disease (Dukes B) in a controlled trial. Second-generation whole cell vaccines include those incorporating genes such as GM-CSF or CD80 (B7-1) to improve immunogenicity, and the use of immunogenic cell membranes such as large multivalent immunogen (LMI). Upregulation of HLA class II molecules and concomitant inhibition of the Ii molecule are also being explored as a strategyfor improved presentation of tumor-associated antigens in vaccines. Complex whole cell-derived vaccines have given clinically superior responses compared to vaccines containing well-defined antigens, such as peptides or gangliosides; however, well-defined vaccines are theoretically more desirable because of their reproducibility.


PMID: 12054065

Other references

Kilbas, S., 1989: Some related opinions from point of view of the members on youth centers in leisure in Ankara, Turkey: a case study at Yenimahalle and Cankaya youth centers. A study was conducted to examine the nature of the services and leisure activities provided by youth centres in Ankara, Turkey, for its members who range between the ages of 12-24 years. The study also investigated the young people's expectat...

Newins, H.S., 1942: Some misnomers of shade trees and ornamentals. The situation with regard to the nomenclature of United States trees is briefly reviewed, and a list is given of some commonly misapplied vernacular and trade names together with suggested corrections. The publication by the U.S. Forest Service in...

Barrington, R.M., 1913: Note on a curious variation of Querquedula crecca. Bulletin of the British Ornithologists' Club, 31 38-39

Gotshalk, Yu. F., 1938: The effect of forests on the moisture of foundation soils and on ground water.. Forest vegetation used more water than did grass. Soil moisture and ground waters increased with the removal of forests.

Pearson, W.; Orth, M.W.; Karrow, N.A.; Maclusky, N.J.; Lindinger, M.I., 2007: Anti-inflammatory and chondroprotective effects of nutraceuticals from Sasha's Blend in a cartilage explant model of inflammation. New Zealand green lipped mussel (NZGLM), abalone (AB), and shark cartilage (SC) are extensively used for treatment of and/or as preventatives for arthritis, despite a relative paucity of scientific evidence for efficacy. This research integrated a...

Duggal, A., 2010: A new perspective. Journal of Hospital Medicine 4(9): 574-575

Gras, David, 2004: Structural dynamics of zooplankton indicator species of the coast of Alacant south east Spain, western Mediterranean. Rapport du Congress de la CIESM 37

Wood, N.J.; Swan, W.W.; Wood, M.M., 1984: The impact of armed conflict on childhood education in developing countries: an economic analysis. A study was made of the percentage of school age population enrolled annually in public or private schools in 103 developing countries over the 11 year period, 1966-1976. To test the hypothesis that the education of children in these countries is...

Bennett, P.R.; Overton, T.G.; Lighten, A.D.; Fisk, N.M., 1995: Rhesus D typing. Lancet 345(8950): 661-662

Anonymous, 1950: HOBBY corner; Stanley Greenhill, M.D. Canadian Hospital 27(5): 41-41