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Cardiac endothelin and big endothelin in right-heart hypertrophy due to monocrotaline-induced pulmonary hypertension in rat


, : Cardiac endothelin and big endothelin in right-heart hypertrophy due to monocrotaline-induced pulmonary hypertension in rat. Cardiovascular Research 44(1): 197-206

Recent observations suggest the existence of a myocardial endothelin (ET) system and its possible involvement in left-ventricular myocardial hypertrophy and failure. However, nothing is known about the role of myocardial ET in right-ventricular hypertrophy. Rats (80-100 g) were given an intraperitoneal injection of saline (controls) or monocrotaline (50 mg/kg) resulting in pulmonary hypertension-induced myocardial hypertrophy (n = 11 in both groups). After 10 weeks, the animals were sacrificed and hearts perfused in vitro to determine levels of big ET-1 and ET-1 in coronary effluent, interstitial fluid and ventricular tissue homogenates; plasma levels were also determined. In monocrotaline-treated animals, weights of right ventricles were 1.5 and of right atria 1.8-fold higher than in controls (p < 0.05), indicating substantial right-ventricular hypertrophy as also evident from greatly increased myocardial production of atrial natriuretic peptide. Left-ventricular weights were not different. Release of big ET-1 in coronary effluent, and of ET-1 in coronary effluent and interstitial transudate were similar in control and hypertrophic hearts (p > 0.05). Disruption of endothelium with collagenase reduced release of both peptides close to zero, indicating endothelial (not myocardial) origin of the peptides. Levels of big ET-1 and ET-1 were similar in left ventricles of both experimental groups, but lower in right ventricles of hypertrophic than control hearts (p < 0.05), reflecting increased tissue mass rather than reduced peptide production. On the other hand, plasma levels of both peptides and of ANP were twofold and levels of angiotensin II 1.3-fold higher in rats with right-heart hypertrophy than in controls (p < 0.05 in each case). These data do not support a role for local cardiac ET-1 and/or big ET-1 in right-ventricular hypertrophy, but point to blood-borne endothelins as possible mediators.

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PMID: 10615403


Other references

Povchun, AS., 1990: Changes in the benthic communities of the Karkinitian Bay of the Black Sea for 50 years. Gidrobiologicheskii Zhurnal, 265: 20-27

Greer, D., 1948: Diagnosis of acute primary atypical pneumonia, etiology unknown, in children. Texas State Journal of Medicine 43(12): 771-775

Fulton, J.; Fuguitt, G.; Gibson, R., 1997: Recent changes in metropolitan-nonmetropolitan migration streams. In this paper, we examine the demographic and socioeconomic characteristics of migration streams between metropolitan and nonmetropolitan areas for four different years over the period 1975-1993. During this period, there have been three shifts in...

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Herruer, M.H.; Kluitenberg, W.E.; Zuijderhoudt, F.M., 1992: Comparison of the ratio HDL-cholesterol/total cholesterol on the Reflotron vs. conventional wet chemistry methods. A new HDL-cholesterol assay using solid phase reagent chemistry on the Reflotron has become available recently. This raises the question of whether the Reflotron now is suited for the determination of the ratio, HDL-cholesterol/total cholesterol,...

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Afanas yev Y.T.; Tomkina A.V., 1981: The petroleum- and gas-bearing capacity of very deep depressions. Pages 3-7 1981

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