geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Chromosomal abnormalities: detection and implications for cancer development


, : Chromosomal abnormalities: detection and implications for cancer development. Anticancer Research 19(6a): 4697-4714

The occurrence of chromosomal abnormalities is a common theme in carcinogenesis. A large proportion of tumours which have been characterized at the cytogenetic level carries numerical and/or structural aberrations. Numerical alterations may include acquisition or loss of specific chromosomes or dramatic changes in overall ploidy levels. Structural aberrations may include DNA amplifications or deletions, inversions and translocations. Many chromosomal alterations occur in a non-random fashion and may be subdivided in to primary and secondary, according to their timing of occurrence. Primary chromosomal abnormalities usually occur at the early stages of tumourigenesis and are often encountered as sole cytogenetic abnormalities. Secondary chromosomal abnormalities are usually associated with more advanced stages of tumour development. In recent years several chromosomal abnormalities could be correlated with specific gene alterations, thus providing insights into the molecular mechanisms underlying tumourigenesis. The biological consequences imparted by other chromosomal changes such as numerical changes are, however, less clear. By using recently developed molecular techniques for chromosome characterization, so-called molecular cytogenetics, our perception on cancer cytogenetics is rapidly changing through the disclosure of hitherto unknown (specific) chromosomal abnormalities.

US$29.90

PMID: 10697586


Other references

Youmans, W.B., 1944: The intestino-intestinal inhibitory reflex. This paper is a summary of the literature concerning the intestino-intestinal inhibitory reflex. A localized distention of any part of the small intestine, if the degree of distention is adequate, may elicit inhibition of the entire small intestin...

Wagner, A.B., 1956: The use of BCG vaccine in the control of tuberculosis. Pennsylvania Medical Journal 59(2): 216-219

Yamoah, C.F.; Mulongoy, K.; Agboola, A.A., 1985: Decomposition and nitrogen contribution by prunings of selected legumes in alley cropping systems. Prunings of Gliricidia sepium, Flemingia congesta and Cassia siamea released 252, 70 and 120 kg N per hectare, respectively. The corresponding maize yield responses were 15, 25 and 50% relative to the control treatment without prunings.

Eder, J.F., 1997: Issues in Forest Conservation: Batak resource management, belief, knowledge and practice. This report was commissioned as one component of a much larger project to achieve more sustainable utilization of non-timber forest products on Palawan Island, Philippines. It involved a collaborative effort by the Batak, an indigenous people, Har...

Bullock, P.; Galatowitsch, M.; Foster, D.; Newhouse, K.; Lewnau, C.; Cook, K.; Bagnali, S.; Chojecki, J.; Guerin, V.; Wilson, M.; Jiao, S., 1994: Phenotypic segregation analysis in elite inbred transgenic maize. In Vitro Cellular & Developmental Biology Animal 30A(3 PART 2): 60

Hledík, E.; Axmann, K.; Kolár, J., 1984: More effective diagnosis of the biliary tract: sonography and instrumental cholangiography. Ceskoslovenska Radiologie 38(1): 51-54

Fleisher, B.; Kulovich, M.V.; Hallman, M.; Gluck, L., 1985: Lung profile: sex differences in normal pregnancy. The incidence of respiratory distress syndrome (RDS) is higher in male than in female infants. The lung profiles--lecithin/sphingomyelin (L/S) ratios, percent disaturated (acetone precipitated) lecithin, phosphatidylglycerol, and phosphatidylinosi...

Arnold, S.R.; Grubb, T.P.; Harvey, P.J., 1995: Recent applications of dissolved air flotation pilot studies and full scale design. The use of Dissolved Air Flotation (DAF) as a solids/liquid separation process in water treatment has been an effective alternative to sedimentation for 70 years. The process was initially applied for removal of materials which had a specific grav...

Sterling, A., 1959: Northern Liberties Hospital; early medical activities. Journal of the Albert Einstein Medical Center, Philadelphia 7(3): 167-168

Rialland, D.; Niquet, C., 1988: Le monde des coquillages. Exposition temporaire organisee par l'AFC. Xenophora, 8-11 No. 42