geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cisplatin/vincristine chemotherapy for hypothalamic/visual pathway astrocytomas in young children


, : Cisplatin/vincristine chemotherapy for hypothalamic/visual pathway astrocytomas in young children. Journal of Neuro-Oncology 37(3): 263-270

Hypothalamic/visual pathway astrocytomas in children are usually quiescent, but certain cases contain aggressive neoplasms that cause progressive neurological and visual deterioration. Radiotherapy is not recommended in young children because of its adverse effects later in life. This report describes the efficacy of a chemotherapeutic regimen. Four young children with hypothalamic/visual pathway astrocytoma, with a mean of 18 months of age at diagnosis, were treated with chemotherapy. Three patients had diencephalic syndrome at the disease's onset. Three patients with pilocytic astrocytoma were histologically verified, and another infant was clinically diagnosed. A combination chemotherapy using cisplatin and vincristine was administered in a total of 8 cycles in 3 children and 4 in one child. One patient who demonstrated renal insufficiency after 4 cycles of this regimen was treated with additional 4 cycles using carboplatin instead of cisplatin. The acute and subacute hematologic and otologic toxicities were mild, and a transient renal insufficiency in a child during chemotherapy improved. After chemotherapy, tumor regression was documented in 3 patients, and the disease was observed to be stable in one patient with an evidence of intratumoral necrosis on MRI. Three patients showed neurological and endocrinological improvements. These results suggest that this regimen is feasible in young children and may be useful as a first-line treatment for hypothalamic/visual pathway astrocytomas, which in turn may allow potentially deleterious irradiation on the maturing brain to be deferred until the disease progresses.

US$29.90

PMID: 9524084


Other references

Imler, J.L.c; Miyajima, A.; Zurawski, G., 1992: Identification of three adjacent amino acids of interleukin-2 receptor b chain which control the affinity and the specificity of the interaction with interleukin-2. The EMBO Journal 11: 47-53

Keller, P.; Schulze, J., 1987: Organ and plasma distribution pattern of enzymes in rainbow trout. The tissue distribution pattern of 10 enzymes commonly used for diagnostic purposes was investigated in the trout. Creatine kinase, fructose-diphosphate aldolase, glutamate dehydrogenase and iditol or sorbitol dehydrogenase (SDH) exhibited a simil...

Gnadt J.W.; Atwood C.W.Jr; Meighen G.A.; Pegram G.V., 1986: Dfp acute toxicity and sleep. Acute administration of the organophosphate dispropyl-fluorophosphate (DFP) produces behavioral and physiological symptoms indicative of excessive cholinergic stimulation. This behavioral toxicity was found to be incompatible with the occurrence o...

Berndt, H.; Gummel, H., 1967: Experiences with stage classification of stomach cancer. Archiv für Geschwulstforschung 30(1): 42-52

Ryabchikov I.D.; Orlova G.P.; Mineyeva R.M.; Bershov L.V.; Korina Y.A., 1985: Experimental data on copper and silver in a granite melt. Geochemistry International 22(2): 22-31

Bruckner I.; Stroescu O.; Stroescu V.; Gheorghiu M.; Suteanu S.; Ghelerter L.; Grozea P.; Barnas M., 1969: Investigations on the effect of azathioprine imuran in rheumatoid arthritis and lupus erythematosus disseminatus. Revue Roumaine de Medecine Interne 6(1): 19-30

Bönsch, D.; Greifenberg, V.; Bayerlein, K.; Biermann, T.; Reulbach, U.; Hillemacher, T.; Kornhuber, J.; Bleich, S., 2005: Alpha-synuclein protein levels are increased in alcoholic patients and are linked to craving. Background: Alpha synuclein has been found to be increased in dopamine neurones of cocaine abusers and in rats whose alcohol preference is inbred. Furthermore, increased alpha-synuclein messenger RNA expression has been linked to craving in patien...

Kamiya, N.; Yuasa, S.; Sekiya, K.; Yamabe, K.; Yamaguchi, Y.; Ubasawa, M., 2001: In vitro antiviral activities of MCC-478 and its metabolites against hepatitis B virus replication. Hepatology 34(4 Pt 2): 621A, October

Ardizzone, S.; Maconi, G.; Bianchi, V.; Russo, A.; Colombo, E.; Cassinotti, A.; Penati, C.; Tenchini, M.L.; Bianchi Porro, G., 2007: Multidrug resistance 1 gene polymorphism and susceptibility to inflammatory bowel disease. Several studies have evaluated the role of the multidrug resistance 1 gene (MDR1) polymorphism, which encodes the membrane-bound efflux transporter P-glycoprotein 170, in determining susceptibility to and disease behavior in inflammatory bowel dis...

Chatanay, J.N., 1977: Capital structures and agricultural prices: reflections on the limitations of Community policy. Over the last few years the average area of large farms has increased in the same proportion as the average area of small farms, and the Community policy of encouraging the latter has not been entirely fulfilled. There is also a prices and income...