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Clozapine and seizures: a review


, : Clozapine and seizures: a review. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie 39(4): 236-238

Clozapine, a novel antipsychotic agent, is an alternative to standard neuroleptic therapy for psychotic disorders. Some advantages of clozapine over neuroleptics are that it may be a more effective antipsychotic in treatment resistant patients and has a lower incidence of extrapyramidal side effects. However, seizures associated with clozapine treatment occur at a rate of about three percent. Factors which seem to increase the likelihood of seizures include high doses of clozapine, rapid dose titration, the concurrent use of other epileptogenic agents and a previous history of neurological abnormalities. A strategy that has been proposed to reduce the occurrence of seizures is the addition of an anticonvulsant agent. At present, little rigorous scientific evidence exists to establish the effectiveness of this strategy or the choice of an anticonvulsant. However, based on what evidence there is and the side effect profiles of the various anticonvulsants, the authors propose the use of valproic acid for the prophylaxis and management of clozapine related seizures.

US$29.90

PMID: 8044732


Other references

Menendez, M.E.; van Hoorn, B.T.; Mackert, M.; Donovan, E.E.; Chen, N.C.; Ring, D., 2016: Patients With Limited Health Literacy Ask Fewer Questions During Office Visits With Hand Surgeons. In the midst of rapid expansion of medical knowledge and decision-support tools intended to benefit diverse patients, patients with limited health literacy (the ability to obtain, process, and understand information and services to make health dec...

Henneman, E.; Dracup, K.; Ganz, T.; Molayeme, O.; Cooper, C., 2001: Effect of a collaborative weaning plan on patient outcome in the critical care setting. The process of weaning from mechanical ventilation can be complex, requiring collaborative care planning by members of the healthcare team. Improved outcomes have been demonstrated to result from collaborative decision-making processes (e.g., when...

Jelke, K.; Neubauer, M.; Krause, G.; Jüttner, A.; Angar, T.; Grosse-Kielisch, C.; Bach, G.L., 1980: Efficacy and tolerance of a new benzbromarone preparation. Die Medizinische Welt 31(21): 821-822

Mccarty, J.M.; Deabate, C.A.drew; Hofer, J.W.; Gabrielson, A.A.; Ahmed, M., 1997: Trimethoprim monotherapy vs trimethoprim + sulfamethoxazole combination therapy for the treatment of children with acute otitis media. Pediatric Research 41(4 PART 2): 126A

Muller, O.; Bartunek, J.; Hamilos, M.; Berza, C.Trana.; Mangiacapra, F.; Ntalianis, A.; Vercruysse, K.; Duby, C.; Wijns, W.; D.B.uyne, B.; Heyndrickx, G.R.; Vanderheyden, M.; Holz, J-Beate.; Barbato, E., 2014: von Willebrand factor inhibition improves endothelial function in patients with stable angina. ALX-0081 is a novel nano-antibody inhibiting von Willebrand factor (vWF). We evaluated whether direct inhibition of vWF by ALX-0081 improves endothelial function. Stable patients (pts, n = 55) with single vessel disease undergoing percutaneous...

Dindo, M.L., 1987: Effects induced by Pseudogonia rufifrons Wied. (Dipt. Tachinidae) on cannibalism and mortality of Galleria mellonella L. (Lep. Galleriidae) placed in conditions of partial starvation. In laboratory rearing experiments with Pseudogonia rufifrons on Galleria mellonella, the effects of insufficient food and parasitism by the tachinid on the rate of cannibalism by the pyralid were compared. In the 1st test, 4 groups of Galleria lar...

Isenhour, Cindy, 2012: The Devil in the Deal Trade Embedded Emissions and the Durban Platform. Several commentators have expressed concern that the Durban Platform does not include more specific language about the need for equitable mitigation efforts. Meanwhile, other commentators have argued that the differentiated approach adopted by the...

Blank, F., 1959: On the isolation and classification of dermatophytes. Following a short account of cultural practices employed in isolating dermatophytes, past and present classifications are reviewed, and the genera and spp. delimited in the widely accepted Emmons classification are discussed.

Pallary, P., 1925: Note sur les fossiles de Maison-Carree recoltes par. M. C. Arambourg. Bulletin de la Societe d'Histoire Naturelle Alger, 16: 312-317

Berleant Schiller, R., 1977: The social and economic role of cattle in Barbuda. The community and economy of Barbuda, the easternmost Leeward island of the Lesser Antilles, differ in important respects from those on other Caribbean islands previously devoted, as Barbuda had not been, to plantation agriculture. Cattle keeping...