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Comparison of intra-amniotic (15S)-15-methyl-PGF2 alpha and intravaginal prostaglandin E2 for second-trimester uterine evacuation

, : Comparison of intra-amniotic (15S)-15-methyl-PGF2 alpha and intravaginal prostaglandin E2 for second-trimester uterine evacuation. Journal of Perinatology 18(1): 24-27

To compare the efficacy, safety, and side effects of intra-amniotic (15S)-15-methyl prostaglandin F2 alpha (15-M-PGF2 alpha) and intravaginal prostaglandin E2 (PGE2) for midtrimester uterine evacuation. Ninety-three patients underwent therapeutic midtrimester pregnancy termination by the use of laminaria placement and intra-amniotic injection of 15-M-PGF2 alpha. A matched control group underwent uterine evacuation by laminaria placement and insertion of PGE2 intravaginal suppositories. The main outcomes studied were time to delivery, side effects, and complications. The 15-M-PGF2 alpha group had a shorter time to delivery (12.3 +/- 6.4 hours) compared with the PGE2 group (16.2 +/- 6.6 hours, p < 0.0001). The evacuation rate over time was significantly greater in the 15-M-PGF2 alpha group (p = 0.001). The PGE2 group had a significantly higher incidence of side effects. The use of intra-amniotic 15-M-PGF2 alpha for therapeutic second-trimester pregnancy termination is safe and is associated with a more rapid evacuation of the uterus and fewer side effects than intravaginal PGF2 suppositories.


PMID: 9527940

Other references

Pertsovskii A.I.; Emel'kin V.I.; Marchuk L.M.; Zadorin Y.G.; Chibireva E.M.; Koval'chuk S.I., 1980: Effectiveness of trypsin electrophoresis in the treatment of patients with chronic bronchitis. Trypsin electrophoresis was used in the complex treatment of 202 patients with chronic bronchitis. This treatment did not cause activation of the kallikrein-kinin or plasmin system or increased adrenal cortex function. Clinico-biochemical investig...

Valyashko M.G.; Vlasova Y.V., 1967: Borate complexes in water solutions. Na (sub 2) O-B (sub 2) O (sub 3) -H (sub 2) O system, infrared spectra.

Arjona-Aguilera, C.; Jiménez-Gallo, D.; Collantes-Rodríguez, C.; Linares-Barrios, M., 2017: Primary Cutaneous Cryptococcosis: A New Case of This Rare Entity. Open Forum Infectious Diseases 4(1): Ofw276-Ofw276

Watson, A.; Lousley, S., 1987: Diabetic cooking with international flair. This collection of international recipes is especially intended for a diabetic diet. The introductory material explains the basic principles of the diabetic diet and how various cooking techniques can be used to adapt international recipes to a lo...

Hillerdal, G., 1997: New principles for the treatment of diffuse pulmonary emphysema. Emphysema is due to destruction of lung tissue but the main cause of the dyspnoea is a diminished elasticity of the lungs. Medical therapy, such as bronchodilation, corticosteroids, and treatment of intercurrent infections, can give temporary reli...

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Kirwan J.; Snow S., 1990: Audit priorities identified by a regional outpatient survey. British Journal of Rheumatology 29(ABSTR SUPPL 2): 83

Bachman, D.M.; Rodrigues, M.M.; Chu, F.C.; Straus, S.E.; Cogan, D.G.; Macher, A.M., 1982: Culture-proven cytomegalovirus retinitis in a homosexual man with the acquired immunodeficiency syndrome. A 35-year-old homosexual man with cytomegalovirus viremia developed retinitis. He also had a new syndrome consisting of a persistent T-lymphocyte deficit, pneumocystis pneumonia, recurrent Candida albicans esophagitis, skin ulcerations caused by h...

Skolnick, A.A., 1991: Melanoma epidemic yields grim statistics. JAMA 265(24): 3217-3218

Nakatsugawa, T.; Iida, Y., 1996: Pseudomonas sp. isolated from diseased ayu, Plecoglossus altivelis. A chronic disease occurred in cultured ayu, Plecoglossus altivelis, from May to July in 1995 in Kyoto and Hiroshima Prefectures. Cumulative mortalities reached 16-30% during that period. One type of bacterium was isolated from the kidney of diseas...