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Contribution on the mode of action of oral ovulation inhibitors in humans. Report 2


, : Contribution on the mode of action of oral ovulation inhibitors in humans. Report 2. Zeitschrift für Geburtshilfe und Gynakologie 171: 1-12

5 women who had taken various ovulation inhibitors for varying duration (3-20 cycles) underwent sterilization in the 1st, 2nd, or 3rd cycle after discontinuing treatment. Urine and tissue samples were taken. Analysis showed that pregnanediol levels of the 3 women who were in the 2nd halves of their cycles corresponded to levels characteristic of a functioning corpus luteum. Tests on another group of women indicated that behavior of the ovarian function depends on length of treatment and individual reaction. Of women who had been taking pills for 1 cycle, a small group had a normal 1st cycle immediately after discontinuation; for others, ovulation was slightly early, prolonging the cycle somewhat at the expense of the proliferation phase - a true ''rebound effect.'' Long-term patients fell into 2 groups: those with longer cycles due to a slightly longer proliferation phase and those who had 1 lengthened anovulatory cycle. By the 2nd cycle, after treatment, all functions were normal again. Returning to the 5 sterilization patients, the histological examination showed functioning corpora lutea by the 2nd cycle. In 1 case, a large mature follicle, normal in all respects, was found on the 14th day of the 1 cycle. Clinical and histological results lead to the conclusion that the ovaries can normalize completely by the 2nd cycle after discontinuation of ovulation inhibitors.

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PMID: 12156324


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