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Cunning simplicity of a hierarchical folding

, : Cunning simplicity of a hierarchical folding. Journal of Biomolecular Structure & Dynamics 20(3): 311-313

A hierarchic scheme of protein folding does not solve the Levinthal paradox since it cannot provide a simultaneous explanation for major features observed for protein folding: (i) folding within non-astronomical time, (ii) independence of the native structure on large variations in the folding rates of given protein under different conditions, and (iii) co-existence, in a visible quantity, of only the native and the unfolded molecules during folding of moderate size (single-domain) proteins. On the contrary, a nucleation mechanism can account for all these major features simultaneously and resolves the Levinthal paradox.


PMID: 12437366

DOI: 10.1080/07391102.2002.10506846

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