geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Curare modification of suxamethonium blockade


, : Curare modification of suxamethonium blockade. Anaesthesia 49(8): 682-685

Tubocurare (0.125 mg.kg-1 or 0.25 mg.kg-1) was injected 10 s before 1 mg.kg-1 suxamethonium in patients anaesthetised with enflurane 1-1.5%. Measurement of electromyographic response was recorded using a 0.2 Hz train-of-four every 20 s. The modified blocks were slower in onset, of lesser intensity, and of shorter duration than that of suxamethonium alone, but were much closer to those of suxamethonium than of tubocurare. However, the train-of-four fade observed during onset of the modified blocks were similar to that of their tubocurare controls and significantly different from the suxamethonium group. We conclude that effective amounts of tubocurare are present in the neuromuscular junction within the 30 s following intravenous injection of the drugs, and this affects the onset of action of the suxamethonium block. The presence of train-of-four fade during a predominantly agonist block is difficult to explain on the basis of diminished acetylcholine release and a postsynaptic site of action of suxamethonium.

US$29.90

PMID: 7943696


Other references

Tundisi, A.G.A.; Lima, F.P.; Kalil, E.B.; Villares, J.B.; Correa, A.; Vidal, M.E.P., 1965: New interpretation of trials on weight gain and viability of economic production of zebu cattle about 24 months old. After weaning at 7 months of age 48 entire male or female Nellore cattle were fed on 4 different nutritional planes. There were 4 feeding systems: cultivated unfertilized pasture alone, pasture with 1 kg daily of a mixture of equal parts of maizem...

Barbadoro, P.; Marigliano, A.; D'Errico, M.Mario.; Carnielli, V.; Prospero, E., 2011: Gestational age as a single predictor of health care-associated bloodstream infections in neonatal intensive care unit patients. Neonates rank among those at highest risk for health care-associated bloodstream infections (BSIs), which are linked to high morbidity and mortality rates. The importance of surveillance in preventing BSIs has been reported; however, a comparison...

Bek, T.; Ledet, T., 1996: Vascular occlusion in diabetic retinopathy: A qualitative and quantitative histopathological study. The retinal vessels from seven diabetic patients and from six age-matched normal controls were studied qualitatively and quantitatively using various histological staining techniques. In diabetic patients the walls of retinal arterioles and capill...

Balantekin, K.N.; Birch, L.L.; Savage, J.S., 2016: Patterns of weight-control behavior among 15 year old girls. The objectives were to identify and predict patterns of weight-control behavior in 15 years old (yo) girls and to examine weight-control group differences in energy intake. Participants included 166 girls assessed every 2 years (ys) from age 5 to...

Murray, R.J., 2005: Recognition and management of Staphylococcus aureus toxin-mediated disease. The ubiquitous human pathogen Staphylococcus aureus is capable of producing a formidable range of extracellular toxins that can have significant deleterious effects on the host. Toxic shock syndrome (TSS) results from infection or colonization wit...

Watling, R.; Asher, A.; Chandler, B.; Mahaffey, L.; Murphy-Fischer, D.; Braveman, B.; DeLany, J.V.; Padilla, Ré.; Reed, K.; Schell, B.; Toto, P.; Gwin, C.H., 2010: AOTA's societal statement on autism spectrum disorders. American Journal of Occupational Therapy 63(6): 843-844

Li, J-Ri.; Wu, C-Cheng.; Chang, C-Yi.; Ou, Y-Chuan.; Lin, S-Yi.; Wang, Y-Yu.; Chen, W-Ying.; Raung, S-Ling.; Liao, S-Lan.; Chen, C-Jung., 2017: Susceptibility of naïve and differentiated PC12 cells to Japanese encephalitis virus infection. Japanese encephalitis is a mosquito-borne disease caused by Japanese encephalitis virus (JEV) infection. Although JEV infects and replicates in cells with multiple tissue origins, neurons are the preferential cells for JEV infection. Currently, th...

Müller-Dietz, H.; von Pettenkofer, M.; Erismann, F., 1969: M. Von Pettenkofer and the Moskow hygienist F. Erismann. (On the 150th birthday of Max von Pettenkofer). Munchener Medizinische Wochenschrift 111(11): 616-621

Wang Y.; Fleet G.W.J.; Storer R.; Myers P.L.; Wallis C.J.; Doherty O.; Watkin D.J.; Vogt K.; Witty D.R.; Wilson F.X.; Peach M.J., 1990: Synthesis of the potent antiviral oxetane nucleoside epinoroxetanocin from d lyxonolactone. A short synthesis of epinoroxetanocin [9-(.beta.-D-threo-oxetanosyl)adenine], free from its .alpha.-anomer, from D-lyxonolactone is described. The X-ray crystal structure of a benzylidene-protected derivative of epinoroxetanocin is reported. A com...

Bardelmeijer, H.A.; Beijnen, J.H.; Brouwer, K.R.; Rosing, H.; Nooijen, W.J.; Schellens, J.H.; van Tellingen, O., 2000: Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein. Previous studies in mice with disrupted mdr1a P-glycoprotein genes have shown that the oral bioavailability of paclitaxel is very low because of the presence of this drug-transporting protein in the intestinal wall. Additional studies with cyclosp...