geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Curative reoperations for locally recurrent rectal cancer


, : Curative reoperations for locally recurrent rectal cancer. Diseases of the Colon and Rectum 39(7): 730-736

Our aims were to determine the morbidity, survival and its influencing factors, and patterns of failure for patients who underwent further surgery with the hope of cure for locally recurrent rectal cancer. Between January 1981 and December 1988, 224 patients with a preoperative diagnosis of recurrent rectal cancer underwent additional surgery at Mayo Medical Center in Rochester, Minnesota. Of these, 65 underwent further surgery with the hope of cure, i.e., no gross/microscopic residual disease at tumor margins after reoperation. Factors assessed included type of original operation, time interval between operation for primary tumor and initial operation for recurrence, symptom status, degree of fixation, types of reoperations for recurrence, and adjuvant therapy. None of the patients died within 30 days of reoperation. Seventeen complications requiring hospitalization and/or surgical procedure were observed in 14 patients. Extended operations (involving partial or complete removal of surrounding organs/structures) required more time to perform, a greater number of transfusions, and a longer hospital stay than more limited operations. Three-year, five-year, and median survival were 57, 34, and 44.7 months, respectively. Survival was greater after curative than after palliative resection (P < 0.001). Survival tended to be greater in females (P < 0.075) and in patients without pain (P < 0.065). Cumulative probability of local failure was 24, 41, and 47 percent at 1, 3, and 5 years, respectively. Cumulative risk of distant metastasis was 30, 51, and 62 percent at 1, 3, and 5 years, respectively. Our results indicate that complete excision of locally recurrent rectal cancer can provide a significant number of patients with long-term survival and can be accomplished safely in select patients.

US$29.90

PMID: 8674362


Other references

Ault C.H.; Carr D.D., 1980: Search for high-calcium limestone in Silurian reefs of northern Indiana. Abstracts with Programs - Geological Society of America 12(5): 218

Luking, K.R.; Pagliaccio, D.; Luby, J.L.; Barch, D.M., 2016: Depression Risk Predicts Blunted Neural Responses to Gains and Enhanced Responses to Losses in Healthy Children. Journal of the American Academy of Child and Adolescent Psychiatry 55(4): 328-337

Garg D.C.; Jallad N.S.; Perez G.; Oster J.R.; Weidler D.J., 1985: Comparative pharmacokinetics of ranitidine in normals and in patients with kidney failure. Journal of Clinical Pharmacology 25(8): 631

Betlejewski, Sław.; Sinkiewicz, A.; Mackiewicz, H.; Owczarek, A.; Dalke, K., 2005: Carbon granuloma--an unwanted effect of laryngeal laser microsurgery. Over recent twenty years, laser microsurgery has gained great recognition in the treatment of early carcinoma. From 1990 to 2004, more than 800 operations on the larynx were performed using laser microsurgery, including 167 chordectomies for squam...

Viggiani, A.; Siani, L.; Notomista, E.; Birolo, L.; Pucci, P.; D.D.nato, A., 2004: The role of the conserved residues His-246, His-199, and Tyr-255 in the catalysis of catechol 2,3-dioxygenase from Pseudomonas stutzeri OX1. Catechol 2,3-dioxygenase (C2,3O) from Pseudomonas stutzeri OX1, which is able to grow on various aromatic substrates as the sole source of carbon and energy, has been expressed in Escherichia coli, purified, characterized, and found to be very sim...

Mcnicholas, Fj, 1976: Experiences with dwarf and semi-dwarf trees in the Champlain Valley. Proceedings of the annual meeting: 21 101-102

Koh M.; Johng T N.; Park I., 1986: Study on the improvement of yield of gamma phosphorus 32 atp synthesis and its purification. We have designed a procedure for the improvement of yield of [.gamma.-32P]-ATP synthesis starting from crude [32P]-H3PO4. Increase of volume of reaction mixture at a constant ratio between the amount of enzymes and reactants increased the yield of...

Saidov, Y.S., 1963: The condition of the commercial fish stocks of Dagestan and means for their rational utilization Fisheries of the inland waters of the USSR. The decline in the Dagestan fish catch is noted. A number of measures are suggested for increasing the reproductive capacity of the stocks.

Steinert, J.; Khalaf, H.; Rimpler, M., 1995: HPLC separation and determination of naphthofuran-4,9-diones and related compounds in extracts of Tabebuia avellanedae (Bignoniaceae). A method for the separation of some naturally occurring quinonoids (naphtho[2,3-b]furan-4,9-diones and related compounds) is reported. These compounds were determined in aqueous and various non-aqueous extracts of the inner bark of Tabebuia avella...

Lustig, R., 2015: Radiation oncology: introduction. Seminars in Oncology 41(6): 701-701