+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Curly fiber and tangle-like inclusions in the ependyma and choroid plexus--a pathogenetic relationship with the cortical Alzheimer-type changes?

, : Curly fiber and tangle-like inclusions in the ependyma and choroid plexus--a pathogenetic relationship with the cortical Alzheimer-type changes?. Journal of Neuropathology and Experimental Neurology 57(12): 1202-1212

The question of whether thread- and tangle-like inclusions of the choroid plexus (known as Biondi inclusions) are related to the cortical lesions in Alzheimer disease (AD) has been debated for almost a century, yet remains unanswered. Recently beta-amyloid protein was biochemically isolated from the plexus, indicating a possible pathogenetic relationship between the degenerative changes of the cerebral cortex and those of the plexus. The goal of the present study was to analyze whether or not a significant correlation exists between the occurrence of the cortical AD-type changes and those in the ependyma and choroid plexus. In 292 consecutive autopsy cases several cortical areas, the ependyma, and the choroid plexus were analyzed to look for AD-type changes and Biondi inclusions using histochemical staining techniques and immunohistochemistry. A semiquantitative analysis of the density of cortical AD-type changes showed that of the 292 cases, 63 had severe cortical changes, 23 moderate changes, and 142 discrete changes. In 64 cases no plaques or neurofibrillary tangles were found. The number of cases with thread- and tangle-like elements in the plexus and ependyma was more than 96% in the 3 groups with cortical AD-type lesions, but low in the group without AD-type cortical changes (19%). The pathological argyrophilic filaments accumulating in the ependymal layer and plexus had histochemical properties of amyloid and were immunoreactive with antibodies to P component, ubiquitin, fibronectin and Tau protein. They did not react with antibodies to neurofilament proteins. Ultrastructurally, they consisted of densely packed straight and paired helical filaments and closely resembled neurofibrillary tangles and neuropil threads. The highly significant correlation (chi2, p = 0.001; R = 0.85) between the occurrence of AD-type changes in the cortex and those in ependyma and plexus suggests a pathogenetic relationship.


PMID: 9862643

Other references

Kuyper, Thomas, W., 2003: Te veel ectomycorrizapaddestoelen?. The author summarizes recent literature on research into the effect on humus depletion by ectomycorrhizal fungi introduced with exotic pine and eucalyptus plantations. Particularly Suillus luteus with saprotrophic as well as ectomycorrhizal charac...

Shahid Hafeez; Khan, Z.H.; Khan, R.A.; Ihsan Qadir; Fahad Rashid, 2007: Comparative efficacy of some trap for controlling porcupines, wild boars and other vertebrate pests. This study was carried out to test entrapping techniques to control porcupine, wild boar and other vertebrate pests, in three rural sites viz., Chak No. 33/J.B, 126/J.B and 197/J.B. of Faisalabad Division, Pakistan, during 2002. In all the cases,...

Alsohaimy, S.A.; Sitohy, M.Z.; E.M.sry, R.A., 2007: Isolation and partial characterization of chickpea, lupine and lentil seed proteins. Recently chickpea lupine and lentil seed proteins have been the focus of chemical and nutritional interest as a good substitute for soybean protein in the preparation of infant formulas and human foods. The purpose of the present investigation is...

Yamaki Y.T., 1988: Differences in juice acidities of citrus species and relationships among acidities and of acidities to potassium concentration. Concentrations of total, free, and combined acids (hereinafter referred to as total acidity, free acidity and combined acidity, respectively) of juice in citrus fruits were determined in 90 samples from 72 citrus species. Potassium concentration o...

Fujioka F.; Matsushita H.; Kuwano M.; Ando H., 1969: The effect of handling rabbits on their growth blood cell concentration and serum components part 2. Bulletin of the Azabu Veterinary College (20): 25-29

Shelden, R.D., 1955: A rubber catheter hook for ether insufflation. Anesthesiology 16(4): 648-648

Fenner H.; Damon R.A.Jr; Barnes H.D., 1969: Effect of ration and time of sampling on ph and certain organic and inorganic rumen fluid components. American Dairy Science Association Proceedings: Second World Conference on Animal Production Xix + 537p Illus Map American Dairy Science Association: Urbana, Ill , U S A : 447-449

Coats J.A.; Brown S.O., 1972: Morphological manifestations following pre natal continuous gamma irradiation in the fetal albino mouse. Texas Journal of Science 23(4): 573

Bugyi, B.; Kausz, I., 1970: Radiographic determination of the skeletal age of the young swimmers. Journal of Sports Medicine and Physical Fitness 10(4): 269-270

Unger, H.; Pittelkow, U.; Schulze, R., 1988: Effects of compaction and deep placement of nitrogen on soil parameters, root growth and yield. Results of soil model experiment at Jena. In a 3-year experiment on a loess parabrown soil placed in containers without or with compression of the 25-45 cm soil layer to simulate a plough pan, compression reduced root growth and penetration and DM yield of Lolium multiflorum var. westerwo...