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Current advances and expectations in tumor immunology

, : Current advances and expectations in tumor immunology. Human Cell 14(3): 159-163

Natural killer (NK) cells and Interferon (IFN)-gamma have been implicated in immune surveillance against tumor. We demonstrated the critical role of perforin in NK cell-mediated cytotoxic activity and anti-tumor effect in IFN-gamma inducible IL-12. And, we recently reported that TRAIL is constitutively expressed on a substantial proportion of murine NK cells in the liver, and which is responsible for spontaneous cytotoxicity and the anti-metastatic activity against TRAIL-sensitive tumor cells along with perforin and Fas ligand. Interestingly, the TRAIL expression on liver NK cells appeared to be regulated by endogenously produced IFN-gamma. Consisting with this finding, IL-12 and NKT cell specific ligand, alpha-Galactosylceramide (alpha-GalCer), induced TRAIL-mediated cytotoxcity and anti-tumor effect, and which was mediated by TRAIL expressed on IFN-gamma-activated NK cells. Tumor necrosis factor(TNF)-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein belonging to the TNF family, which preferentially induces apoptotic cell death in various tumor cells in vitro. Preclinical studies in mice and nonhuman primates have shown that administration of recombinant soluble forms of TRAIL could suppress the growth of TRAIL-sensitive tumor xenografts with no apparent systemic toxicity. These studies suggested a potential utility of TRAIL as a cancer therapeutic, although TRAIL expression at protein levels and its physiological roles in tumor surveillance has remained unknown. Presented findings provide the first evidence for the physiological function of TRAIL as a tumor suppressor.


PMID: 11774735

Other references

Blom, U.P.; Hoek, J.M. van den, 1988: How the wives of farmers and nurserymen spend their time. The results are reported of a study of how farmers' and nurserymen's wives spend their days. The study is based on diaries kept for a week in the summer of 1982. The wives spend an average of 47 hours per week on domestic and family duti...

Maehlum, J., 1981: Calf of moose in January. A red-brown calf of moose A. alces observed on Jan. 25, 1981, near the southern coast in Aust-Agder Norway , was probably 3 mo. old. This indicates a birth at the end of Oct. (.apprx. 5 mo. later than normal). The copulation should then be at the...

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Franceschetti, A.T., 1976: Fabry disease: ocular manifestations. Fabry disease involves the different eye structures with variable frequencies. Typical alterations are the vascular lesions of the conjunctiva, the whirl-like opacities of the cornea, the wedge-shaped anterior opacities and the branching spokes of...

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Robins, J.; Pike, M., 1990: The validity of case-control studies with nonrandom selection of controls. An unbiased estimate of the rate ratio can be obtained using a case-control design in which each case is matched to one or more controls randomly selected from population members at risk and in the same stratum as the case at the time of disease o...