geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Current and future contributions of transgenic mice to the analysis of germline toxicology


, : Current and future contributions of transgenic mice to the analysis of germline toxicology. Advances in Experimental Medicine and Biology 444: 119-25; Discussion 125-7

Evermore sophisticated tests are need to study germline toxicology. The gene conversion-based systems developed in Leicester and in the USA are steps in the right direction, but a lot of validation both in vivo and in vitro is required. Transgenic technology can also be used to research the biology of testis, so that we know more how to make it more human-like. If you talk to toxicologists, they always complain: 'but it 's only a rat, it's only a mouse, it's not a man'. In future, once we understand more biology--it might be possible to make the toxicological response of a transgenic mouse more human-like. As we all know, the testis is a complex biological system and it is only when we get a better understanding of what is going on to the fundamental level are such developments possible. Indeed, it might be possible to do even more exciting things, such as taking mitotic human tissue culture cells and to inducing them to enter meiosis in vitro. Such a system would be a natural complement to the in vitro tests widely used in industry.

US$29.90

PMID: 10026941


Other references

Reyes, G.R.; Hadlock, K.G., 1998: HTLV-II peptide antigens. Official Gazette of the United States Patent & Trademark Office Patents 121(2): 1740, June 9

Pedersen C.T.; Dinesen A.R.; Hviid S.F.; Madsen M.B.; Knudsen J.M.; Gunnlaugsson H.P.; Goetz W.; Hargraves R.B., 1998: Laboratory experiments simulating the results of the magnetic properties experiment on Mars Pathfinder. Abstracts of Papers Submitted to the Lunar and Planetary Science Conference 29(1998

Fry, D.L.; Nobel, F.W.; Mallos, A.J., 1957: An electrical device for instantaneous and continuous computation of aortic blood velocity. It has been previously shown that the instantaneous axial pressure gradient in the aorta has two components, an inertial term and a frictional term. The differential equation describing the pressure gradient has as an analog the equation describin...

Inada, K.; Iwashima, Y.; Okada, A.; Matsumoto, K., 1974: Nonatherosclerotic segmental arterial occlusion of the extremity. Archives of Surgery 108(5): 663-667

Rigden, R.C.; Carrasco, C.P.; Summerfield, A.; McCullough, K.C., 2002: Macrophage phagocytosis of foot-and-mouth disease virus may create infectious carriers. Macrophages play critical roles in innate defences against virus infections, particularly pertinent to the rapid immune response required following emergency vaccination against foot and mouth disease virus [Aphthovirus] (FMDV). Consequently, macr...

Ross, C.A.; Joshi, S., 1992: Paranormal experiences in the general population. The Dissociative Disorders Interview Schedule was administered to a random sample of 502 adults in the general population of Winnipeg, a midwestern Canadian city. Results showed that paranormal/extrasensory experiences were common in the general p...

Njolstad, P.R.; Reigstad, H.; Westby, J.; Espeland, A., 1998: Familial non-immune hydrops fetalis and congenital pulmonary lymphangiectasia. We report on three siblings with non-immune hydrops fetalis. Congenital pulmonary lymphangiectasia was diagnosed in two of them. One of these, a girl still alive and suffering from frequent airway infections, has bilateral pleural effusions and di...

Draganov, I., 1975: Some problems of economic effect. Gorskostopanska nauka: 2 (4) 75-82

Anonymous, 1984: Nurses sue hospital to get jobs back. Kansas Nurse 59(10): 6-7

Miller, J.H.; Swartzwelder, J.C., 1962: Does Entamoeba histolytica have mitochondria ?. Journal of Parasitology, 48: 34