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Current and future developments in the use of temozolomide for the treatment of brain tumours

, : Current and future developments in the use of temozolomide for the treatment of brain tumours. Lancet. Oncology 2(9): 552-560

Brain tumours comprise only 2% of all adult cancers, but they are among the most debilitating malignant diseases. Temozolomide, an alkylating agent that can be administered orally, has been approved for the treatment of recurrent malignant glioma on a daily schedule for 5-day cycles. Continuous administration schedules with a higher dose intensity are being explored, but an improvement in efficiency remains to be shown. The benefit from temozolomide given as a single agent in recurrent disease will be several weeks at best. This drug is therefore now undergoing clinical testing as neoadjuvant chemotherapy or with concomitant radiotherapy in patients with newly diagnosed glioma. Several phase I trials are investigating the combination of temozolomide with other agents active against brain tumours. This review briefly summarises the pharmacological background and clinical development of temozolomide and focuses on current and future clinical exploration of this drug for the treatment of brain tumours.


PMID: 11905710

DOI: 10.1016/S1470-2045(01)00489-2

Other references

Zou ChuJing; X.W.nDuo; Zhang Yuan; Liu GuangTian, 1998: Compensation and overcompensation effects of Pinus mongolica seedlings damaged by leaf-eating insects. An experiment simulating defoliation caused by leaf-eating insects was carried out to study the interaction between plants and insects in the ecosystem. The results showed that at a certain rate of defoliation seedlings of Pinus sylvestris var. mo...

Cox, F., 1967: Staffing of nurising personnel spinal cord injury service. Proceedings. Clinical Spinal Cord Injury Conference 16: 111-112

Konishi, M.; Watanabe, M., 1995: Molecular size-dependent leakage of intracellular molecules from frog skeletal muscle fibers permeabilized with beta-escin. The permeability of beta-escin-treated cell membrane was characterized in terms of the permeant molecular size, by monitoring the leak of cytoplasmic molecules in frog skeletal muscle fibers. With a low concentration of beta-escin (5 microM), most...

Hering, J.; Steudtner, J.; Meyer, H., 2000: Notable observations in Saxony March to August 2000 Bemerkenswerte Beobachtungen in Sachsen Maerz bis August 2000. Rundschreiben des Vereins Saechsischer Ornithologen. November; 18: 27-33

Bazylak, G.; Nagels, L.J., 2002: Potentiometric detection of exogenic beta-adrenergic substances in liquid chromatography. Potentiometric detection with poly(vinyl chloride) (PVC) based liquid membrane electrode coatings is presented for a series of 18 exogenic beta-adrenergic substances in cation-exchange-HPLC and RP-HPLC systems. In both types of HPLC modes employin...

Fitzgerald Duncan M., 1984: Coastal geology of Winthrop, MA. Annual Meeting - New England Intercollegiate Geological Conference, Guidebook 76: 1-24

Chang, L-Chu.; Yu, Y-Luen.; Hsieh, M-Tsang.; Wang, S-Hung.; Chou, R-Hwang.; Huang, W-Chien.; Lin, H-Yi.; Hung, H-Yi.; Huang, L-Jiau.; Kuo, S-Chu., 2016: A novel microtubule inhibitor, MT3-037, causes cancer cell apoptosis by inducing mitotic arrest and interfering with microtubule dynamics. We investigated the anticancer potential of a new synthetic compound, 7-(3-fluorophenyl)-4-methylpyrido-[2,3-d]pyrimidin-5(8H)-one (MT3-037). We found that MT3-037 effectively decreased the cancer cell viability by inducing apoptosis. MT3-037 trea...

Pavel, S.; Cristoveanu, A.; Goldstein, R.; Calb, M., 1977: Inhibition of release of corticotropin releasing hormone in cats by extremely small amounts of vasotocin injected into the third ventricle of the brain. Evidence for the involvement of 5-hydroxytryptamine-containing neurons. Endocrinology 101(3): 672-678

Shaheen, A.Am.; Somayaji, R.; Myers, R.; Mody, C.H., 2017: Epidemiology and trends of cryptococcosis in the United States from 2000 to 2007: A population-based study. Cryptococcal disease, caused by Cryptococcus neoformans and Cryptococcus gattii, is associated with significant morbidity and mortality but limited data exist on its incidence and impact. A study utilizing the Nationwide Inpatient Sample from 2000...

Sidorov, S.N.; Volkov, I.V.; Davankov, V.A.; Tsyurupa, M.P.; Valetsky, P.M.; Bronstein, L.M.; Karlinsey, R.; Zwanziger, J.W.; Matveeva, V.G.; Sulman, E.M.; Lakina, N.V.; Wilder, E.A.; Spontak, R.J., 2001: Platinum-containing hyper-cross-linked polystyrene as a modifier-free selective catalyst for L-sorbose oxidation. Impregnation of hyper-cross-linked polystyrene (HPS) with tetrahydrofuran (THF) or methanol (ML) solutions containing platinic acid results in the formation of Pt(II) complexes within the nanocavities of HPS. Subsequent reduction of the complexes...