geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Current and future drug therapies for claudication


, : Current and future drug therapies for claudication. Vascular Medicine 2(3): 257-262

The primary objectives of claudication treatment are to reduce cardiovascular mortality and improve walking ability. Patients with claudication have 60% mortality over 10 years, with most deaths due to myocardial infarction and stroke. Aggressive risk-factor modification is required in all these patients, particularly smoking cessation, lipid modification, and treatment of hypertension, diabetes and elevated homocysteine levels. Aspirin, ticlopidine and clopidogrel are all effective in reducing the risk of myocardial infarction, stroke and vascular death, and thus antiplatelet therapy should be considered in all claudicants. Patients with disabling claudication should be considered for therapies that relieve claudication pain and improve exercise performance, the most effective being exercise training and smoking cessation. Pentoxifylline, the only approved claudication drug in the United States, has modest efficacy in improving treadmill exercise performance. Other drugs shown to be of some benefit in patients with claudication include propionyl-L-carnitine, cilostazol and possibly prostaglandin derivatives. Several antiplatelet agents and angiogenic growth factors are also being evaluated for the treatment of claudication.

US$29.90

PMID: 9546977


Other references

Rüthrich, H.L.; Grecksch, G.; Matthies, H., 1985: Influence of postnatal hypoxia on learning and memory formation of adult rats. Male Wistar rats were exposed to a single normobaric hypoxic treatment at the age of either 15 or 20 days. Two different kinds of hypoxia were used: 4% O2 for 6 h or 3.5% O2 for 40 min. At the age of 8 weeks the acquisition and retention of a brig...

Nishiyama R.; Kozaki M., 1984: Inhibitory function of kakishibu persimmon tannin toward cell growth of microorganisms. Hakkokogaku Kaishi 62(1): 9-14

Toya, D.K.; Frazier, W.A.; Morgan, M.E.; Baggett, J.R., 1974: The influence of processing and maturity on volatile components in bush snap bean, Phaseolus vulgaris L. The concentration of 17 volatile components in canned, frozen and fresh green bean pods was determined by GLC. Only 1-octen-3-ol differed quantitatively with the cultivar. In fresh green beans the concentration of 1-octen-3-ol was highest early in...

Hamelers, H.V.M., 2001: A mathematical model for composting kinetics. The objective of this thesis is to develop a mechanistic model of the composting process whose parameters are all identifiable. The thesis considers: the objectives for composting; the composting process; the composting plant; modelling concepts;...

Lewy Ze ev, 2003: Lower Aptian trace fossils in marginally marine sandstone and their extant analogues. The Hatira Formation in the Negev (southern Israel) consists mainly of terrestrial variegated sandstone with plant remains. The Tethys Sea periodically inundated the region from the northwest, depositing partly calcareous horizontal beds. A sandst...

Sprang, S.R., 1992: The latent tendencies of PAI-1. Trends in Biochemical Sciences 17(2): 49-50

Kumar, S.; Verma, R.N., 1985: Soyabean rust in N.E. hills of India: further observations. Phakopsora pachyrhizi has now been identified in all the NE Hills States, including Sikkim. Urediospores on infected soyabean leaves stored for >15 d at either room temp. or 25 degrees C failed to germinate. Rust infection caused losses in yiel...

Petit, Y.; Boulanger, Bît.; Segonds, P.; Félix, C.; Ménaert, B.; Zaccaro, J.; Aka, Gérard., 2008: Absorption and fluorescence anisotropies of monoclinic crystals: the case of Nd:YCOB. We report for the first time measurements and modelization of the angular distributions of absorption and fluorescence in a monoclinic crystal. Studies on Nd:YCOB revealed specific topologies with ombilics. These new data upgrade the knowledge on...

Mushi, P.A.K., 1987: Some correlates of literacy rates in selected African countries. This paper investigates literacy rates of selected African countries and determines whether these rates are correlated with other variables, such as GNP per caput income, expenditure on education, enrolment rate, life expectancy, crude birth rates...

Harlan J.B.; Harris D.A.; Mallette P.M.; Norby J.W.; Rota J.C.; Sagar J.J., 2002: Geology and mineralization of the Maggie Creek District. Bulletin - Nevada Bureau of Mines and Geology Pages 115-142