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Current and future therapies for airway mucus hypersecretion

, : Current and future therapies for airway mucus hypersecretion. Novartis Foundation Symposium 248: 237-49; Discussion 249-53, 277-82

Mucus hypersecretion is a prominent feature of chronic inflammatory diseases of the airways, including asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis, but little is known about the effects of current therapies for airway disease because of the difficulties in quantifying mucus hypersecretion in clinical studies. Anticholinergics may reduce mucus hypersecretion, whereas beta2 agonists and mucolytics have little obvious effect. Corticosteroids are highly effective in inhibiting mucus hypersecretion in asthma by suppressing the underlying inflammatory process, but are ineffective in COPD and cystic fibrosis. Novel approaches in the future may include inhibition of sensory neuropeptides by tachykinin antagonists, modulators of sensory nerves or K+ channel openers. Inhibition of Th2 cytokines (interleukin [IL]4, IL9, IL13) may also be effective in asthma. In COPD inhibition of neutrophil-derived proteases by small molecule inhibitors or inhibiting neutrophilic inflammation in the airways by reducing neutrophil chemotaxis may also be effective strategies. Several novel targets involved in mucus hypersecretion have recently been identified, including epidermal growth factor receptors, MARCKs, Ca2+-activated Cl- channels and mitogen-activated protein kinases. However, the clinical benefits from inhibiting mucus hypersecretion are still not certain, casting some doubts on this therapeutic approach.


PMID: 12568498

Other references

Singh, S.B.; Kollman, P.A., 1996: Understanding the thermodynamic stability of an RNA hairpin and its mutant. The thermodynamic stability of RNA hairpin loops has been a subject of considerable interest in the recent past (Wimberly et al., 1991). There have been experimental reports indicating that the hairpins with a C(UUCG)G loop sequence are thermodyna...

Munoz, I.; Gutierrez, A.; Gimeno, C.; Farga, A.; Alberola, J.; Solano, C.; Prosper, F.; Garcia Conde, J.; Navarro, D., 2001: Lack of association between the kinetics of human cytomegalovirus glycoprotein B -specific and neutralizing serum antibodies and development or recovery from HCMV active infection in patients undergoing allogeneic stem cell transplant. The kinetics of the gB-specific and neutralizing antibody responses to human cytomegalovirus (HCMV) were analyzed in 26 allogeneic stem-cell transplant recipients who either did (n=20) or did not (n=6) develop asymptomatic HCMV active infection du...

Senior, K., 2011: New vaccination technologies that make needles redundant. Lancet. Infectious Diseases 11(1): 16-17

Mitsuyo, T.; Dutton, R.C.; Antognini, J.F.; Carstens, E., 2006: The differential effects of halothane and isoflurane on windup of dorsal horn neurons selected in unanesthetized decerebrated rats. Halothane and isoflurane, in the peri-minimum alveolar anesthetic concentration (MAC) range, exert differential effects on spinal nociceptive neurons, whereby halothane further depresses their responses from 0.8 to 1.2 MAC, whereas isoflurane does...

Klopfenstein, T., 1994: Crop residue use as animal feed. This chapter reviews composition of crop residues and their current uses. The use of maize stover for grazing and the increasing use of crop residues particularly after chemical treatment (ammonia, calcium hydroxide and oxidizers) are also covered...

Anonymous, 1978: From the NIH: echocardiographic studies indicate that with age, left ventricular filling rate decreases substantially. JAMA 240(24): 2625-2625

Bolick, D.T.; Mayneris-Perxachs, J.; Medlock, G.L.; Kolling, G.L.; Papin, J.A.; Swann, J.R.; Guerrant, R.L., 2017: Increased Urinary Trimethylamine N-Oxide Following Cryptosporidium Infection and Protein Malnutrition Independent of Microbiome Effects. Cryptosporidium infections have been associated with growth stunting, even in the absence of diarrhea. Having previously detailed the effects of protein deficiency on both microbiome and metabolome in this model, we now describe the specific gut m...

Nicholson, EM., 1977: Sir Landsborough Thomson, CB, OBE, DSc, Hon. LLD (1890-1977). British Birds, 709: 384-386

Laurent-Vannier, A.; Chevignard, M.; Pradat-Diehl, P.; Abada, Gève.; D.A.ostini, M., 2006: Assessment of unilateral spatial neglect in children using the Teddy Bear Cancellation Test. The purpose of the study was to provide normative data for the Teddy Bear Cancellation Test (TBCT) and to evaluate prospectively the frequency of unilateral spatial neglect (USN) in children with acquired brain injury (ABI). In the control group (...

Tillquist, C.F.; Adler, C.P.; Stini, W.A., 1997: Longitudinal bone density data of peri- and postmenopausal women A report of the Arizona Bone Density Study. American Journal of Physical Anthropology 0(SUPPL 24): 228