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Current and future uses of recombinant interferon alpha in the treatment of low-grade non-Hodgkin's lymphoma


, : Current and future uses of recombinant interferon alpha in the treatment of low-grade non-Hodgkin's lymphoma. Cancer 59(3 Suppl): 658-663

Recombinant and natural forms of interferon alpha have been shown to bring about tumor regressions in patients with low-grade non-Hodgkin's lymphoma. Complete and partial response rates in up to 50% of patients have been documented. Although these studies are encouraging, interferon alpha's role in the current management of patients with low-grade non-Hodgkin's lymphoma is not apparent. The high doses of interferon that were used in some of the recent studies were not well tolerated by these patients. Current studies using interferon in patients with low-grade non-Hodgkin's lymphomas are evaluating lower, and perhaps better tolerated doses of interferon. In addition, in vitro studies have documented additive and sometimes synergistic antitumor effects of interferon in combination with cytotoxic drugs. This approach is being extended to the clinic, and trials are now underway evaluating combinations of interferon and various cytotoxic drugs known from previous studies to be active in patients with low-grade non-Hodgkin's lymphomas. This report reviews studies using interferon alone in these patients, and discusses ongoing and proposed studies for the future use of interferon in treating this disease.

US$29.90

PMID: 10822466


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Fujioka, R.; Aoyama, T.; Takakuwa, T., 2014: The layered structure of the articular surface. Articular cartilage is roughly separated into 3 areas: the tangential, middle, and deep zones. The structure and molecular components of an additional important zone, the most superficial zone (MSZ), which directly faces the joint cavity, have yet...

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Basnak'ian, I.A.; Dubinina, G.P., 1974: Morphological characteristics verus the physiological and biochemical regularities of the activity of microoroganisms during periodic and continuous cultivation (literature review). Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii: 3-8

Chamruspanth, V., 1987: The interorganizational cooperation and conflict among agricultural support organizations in Khon Kaen Province, Thailand. Interorganizational cooperation or conflict among agricultural support organizations affects the efforts of agricultural development. Several sociological theories were used to provide a backdrop for understanding interorganizational relationships...

Kozminski, C., 1983: Soil temperature forming at the depth of 5 centimeters at the agrometeorologic station in Lipki by Stargard depending on meteorologic factors. Zeszyty naukowe Academia Rolnicza w Szczecinie0(30): 81-92

Ramos, R.L.; Bunce, J.G.; Sabolek, H.S.; Amaral, D.G.; Chrobak, J.J., 2002: Entorhinal innervation of the rat hippocampus anterograde tracing of the projections to the dentate, ca3 and ca1. Investigation of the broad network, local circuit, and microcircuit anatomy of the)hippocampal formation will provide a critical map for understanding the physiology and emergent function of hippocampus. Previous studies have described intrinsic e...

Anonymous, 1988: Domestic humidifiers to replace moisture. NlmCategory="UNASSIGNED">A new range of domestic humidifiers are available via JS Industrial Services Ltd.

Zhou, Y.; Irwin, M.L.; Risch, H.A., 2011: Pre- and post-diagnosis body mass index, weight change, and ovarian cancer mortality. The purpose of this study was (1) to investigate the association between BMI self-reported at three time points (during their 20s, 5 years before diagnosis, and post-diagnosis) and mortality among 388 women with newly diagnosed epithelial ovarian...

Hargrove, R.E., 1962: Control of bacteriophage. It is claimed that a milk medium resistant to bacteriophage growth is obtained by heating starter milk, containing 1.3% of added phosphate mixtures and having a pH of 6.3-6.9, at 80 degrees -100 degrees C for 15-30 min. The milk is then cooled dow...

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