geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Current and planned clinical trials with trastuzumab (Herceptin)


, : Current and planned clinical trials with trastuzumab (Herceptin). Seminars in Oncology 27(5 Suppl 9): 27-32

Trastuzumab (Herceptin; Genentech, Inc, So. San Francisco, CA) is a high-affinity, humanized anti-HER2 antibody that has shown benefit in the therapy of patients with metastatic HER2-overexpressing breast cancer. Results from initial clinical trials of trastuzumab as a single agent or in combination with chemotherapy established important guidelines for the therapy of HER2-positive tumors, but represent an early phase of clinical development. Preclinical studies have shown additive and synergistic effects of trastuzumab when given in combination with several chemotherapeutic agents, and a series of clinical trials exploring these new combinations is under way or will be started shortly. Substantial effort will be directed toward promising schedules and combinations, such as weekly paclitaxel with trastuzumab or combinations of platinum, taxanes, and trastuzumab. Due to the unexpected cardiac toxicity observed with the combination of doxorubicin plus trastuzumab, new studies will be designed to prospectively assess cardiac function and will incorporate anthracyclines with less cardiotoxicity, such as liposomal doxorubicin. Combination studies are not limited to cytotoxic agents, as laboratory and clinical data have demonstrated that HER2 overexpression results in resistance to hormonal therapy. Therefore, a series of studies combining hormonal treatments with trastuzumab is being considered. Finally, the integration of trastuzumab into the adjuvant and neoadjuvant settings will be studied by United States and European cooperative groups.

US$29.90

PMID: 11049054


Other references

Merriman, P.R.; Price, R.D.; Kollmorgen, J.F.; Piggott, T.; Ridge, E.H., 1974: Effect of seed inoculation with Bacillus subtilis and Streptomyces griseus on the growth of cereals and carrots. B. subtilis (A13) and S. griseus (2-A24), both antagonistic to Rhizoctonia solani, were applied individually to barley, oats and wheat for sowing at 3 sites with a known incidence of R. solani. Root disease was not effectively controlled but the t...

Milana, J.-Pablo; Tietze, K.-Werner, 2007: Limitations of sequence stratigraphic correlation between marine and continental deposits: a 3D experimental study of unconformity-bounded units. Experiments have been carried out in a model basin 16 x 1.2 x 0.9 m to address the effect of base-level and discharge changes on actively growing alluvial-shoreline wedges. Two distinct types of erosive surfaces were investigated: one produced by...

Schoenhagen, P., 2007: The role of coronary CT angiography (CTA) for patients presenting with acute chest pain. Defining problem-specific, evidence-based indications of a novel imaging modality. In the current issue, Stillman et al. (Int J Cardiovasc Imaging, 2007) discuss the role of coronary CTA in patients presenting with acute chest pain. The authors conclude, that CTA will provide novel information on the presence and significance of...

Fernandez Rozas, F., 1951: Correct method of la parotomy for approach of the biliary tract. La Semana Medica 99(3): 102-107

Nanda, Kk, 1983: Hormones and flowering. Advancing frontiers plant sciences 1983: symposium proceedings National Symposium on Advancing Frontiers of Plant Sciences Jodhpur November 26-30-1983 edited by HC Arya et al: IV

Daly, A.K.; Brockmöller, J.; Broly, F.; Eichelbaum, M.; Evans, W.E.; Gonzalez, F.J.; Huang, J.D.; Idle, J.R.; Ingelman-Sundberg, M.; Ishizaki, T.; Jacqz-Aigrain, E.; Meyer, U.A.; Nebert, D.W.; Steen, V.M.; Wolf, C.R.; Zanger, U.M., 1996: Nomenclature for human CYP2D6 alleles. To standardize CYP2D6 allele nomenclature, and to conform with international human gene nomenclature guidelines, an alternative to the current arbitrary system is described. Based on recommendations for human genome nomenclature, we propose that a...

Bouchard, M.; Furtado, S., 2012: Speech-induced cervical dystonia. Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques 38(6): 929-930

Soshnikov, E.I.; Durinian, R.A.; Safonov, V.A., 1969: The activity of respiratory neurons in the absence of respiratory movements. Biulleten' Eksperimental'noi Biologii i Meditsiny 68(12): 7-9

Karlsson V.; Hasanen E.; Nordlund O.P., 1985: Major inorganic ions in north pole snow samples. Major inorganic ions, pH, total N and P were analyzed in 8 arctic snow samples collected in March, April and May 1984 during an expedition in the North Pole region (N83.degree.18' W73.degree.06' - N89.960.degree.). The concentrations of...

Küstner, M.; Tost, F., 2006: Use of high-frequency ultrasound for follow-up and visualization of intracanalicular plugs. European Journal of Ophthalmology 16(2): 354-355