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DDAVP nasal spray for treatment of menorrhagia in women with inherited bleeding disorders: a randomized placebo-controlled crossover study

, : DDAVP nasal spray for treatment of menorrhagia in women with inherited bleeding disorders: a randomized placebo-controlled crossover study. Haemophilia 8(6): 787-793

To assess DDAVP (1-deamino-8-d-arginine vasopressin; desmopressin) nasal spray in the management of menorrhagia in patients with inherited bleeding disorders, 39 women (aged 18-50 years) with menorrhagia were recruited and were randomized to start 2 months' therapy with placebo or DDAVP (300 micro g) spray in a double-blind crossover study. Twenty-eight and 24 completed first and second period of treatment, respectively. Menstrual loss was assessed using the pictorial blood assessment chart (PBAC) during each treatment period. The main outcome measure was comparison of PBAC scores following DDAVP and placebo treatments. The safety of DDAVP spray was also assessed by monitoring side-effects. Overall, PBAC scores were significantly lower in the second treatment period than the first (P = 0.01). After adjusting for this differences, mean PBAC scores were slightly lower (mean difference 8; 95% confidence interval of - 15.5 to 31.6) in women receiving DDAVP than when receiving placebo, although this difference was not statistically significant (P = 0.51). In conclusion, although there was an indication that menstrual bleeding was less heavy when women received DDAVP than when receiving placebo, the small sample size meant that this difference was not significant.


PMID: 12410648

Other references

Lloyd, M.D.; Mukherji, M.; Kershaw, N.; Mackinnon, C.H.; Schofield, C.J.; Wierzbicki, A.S., 2000: Unnatural co-substrate-based rescue of enzyme activity in Refsums disease resulting from mutations in R275 of phytanoyl-CoA hydroxylase. American Journal of Human Genetics 67(4 Supplement 2): 297, October

Rose, S.K.; Conn, V.S.; Rodeman, B.J., 1994: Anxiety and self-care following myocardial infarction. The purpose of this study was to examine the relationship between trait and state anxiety experienced during hospitalization for an acute myocardial infarction and self-care behaviors several weeks after the infarction. Sixty-two male (n = 39) and...

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Drekic D.; Malobabic S., 1987: A simple modified of the golgi method. A simple and successful modification of the Golgi method is described. The proposed procedure is based on the von Bubenaite modification, but without embedding in paraffin and including some other, slightly different steps. Fixation by perfusion w...

Grigoryuk, I.A., 1981: A comparative study of the metabolism of 14C-glucose and certain amino acids in potato tubers grown in different soils. Peculiarities of 14C-glucose, alanine, glycine and tyrosine metabolism were studied at 3 stages of potato tuber growth in 2 soils. Starch biosynthesis and tuber wt./plant were both less at various stages of tuber formation in potato cv. Sulev grow...

Novoa, C., 1987: Improvement of Andean camelids. The reproduction, health, nutrition and genetic improvement through selection of alpacas in Peru are discussed.

Stonier T.; Hudek J.; Vande Stouwe R.; Yang H M., 1970: Studies of auxin protectors part 8 evidence that auxin protectors act as cellular poisers. Physiologia Plantarum 23(4): 775-783

Nash, D.T.; Boll, W.G., 1975: Carbohydrate nutrition of Paul's Scarlet rose cell suspensions. Paul's Scarlet rose cells grew equally well on glucose, fructose, or trehalose as a source of carbohydrate. When fructose-containing medium was autoclaved, it became inhibitory to growth. As cells entered the stationary phase, they became pro...

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Sudoł-Szopińska, I., 2006: Influence of prolonged sedentary work on the development of lower limbs edema and methods of its prevention. Prolonged sitting may lead to numerous complications of general nature such as fatigue or discomfort, but also to diseases of the musculosceletal system (the spine and upper limbs), chronic veins insufficiency, deep veins thrombosis as well as obe...