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Determination of lipoproteins defined following their apolipoprotein composition for the prediction of cardiovascular risk


, : Determination of lipoproteins defined following their apolipoprotein composition for the prediction of cardiovascular risk. Annales de Biologie Clinique 52(3): 179-183

Immunological methods permit separation and measurement of lipoprotein concentrations in terms of their apolipoprotein composition. We have elaborated two different methods to measure lipoprotein particles in plasma. The first is a selective bi-site Elisa procedure and the second a differential electroimmunoassay. Lp A-I plays an essential role in reverse cholesterol transport. We have shown that Lp A-I is an anti-risk marker of atherosclerosis. Its concentration is higher in females than in males, it is decreased in patients with coronary heart disease and in their kindreds and in populations with a high cardiovascular risk. This fraction is increased in octogenarians. In pharmacological terms, HMG CoA reductase inhibitors increase Lp A-I and Lp A-I:A-II while fenofibrate decreases Lp A-I and increases Lp A-I:A-II. These studies demonstrate that the measurement of lipoprotein concentrations according to their apolipoprotein composition can reveal lipoprotein fractions that have precise metabolic roles with epidemiological and pathophysiological implications.

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PMID: 7998673


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