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Development and treatment of pulmonary metastases in adult patients with extremity soft tissue sarcoma


, : Development and treatment of pulmonary metastases in adult patients with extremity soft tissue sarcoma. Annals of Surgery 218(6): 705-712

The authors reviewed a series of adult patients with extremity soft tissue sarcoma to determine the incidence of pulmonary metastases and outcome after treatment. Of 716 patients admitted between January 1983 and December 1990, 135 (19%) had isolated pulmonary metastases as the initial site of distant recurrence. Fifty-eight percent (78 of 135) of the patients were treated surgically, and 83% of them had their tumors completely resected. The median survival after complete resection was 19 months; incomplete resection, 10 months; and no operation, 8 months (p = 0.005). The 3-year survival rate after complete resection was 23%, compared with a 2% rate (1 of 57) in those treated nonsurgically (p < 0.001). Factors associated with an increased risk of pulmonary metastases included high tumor grade, tumor size greater than 5 cm, lower extremity site, and histologic type (spindle cell, tendosynovial, and extraskeletal osteosarcoma). Factors associated with complete resectability were the histologic types of spindle cell and extraskeletal osteosarcoma. Complete surgical resection remains the only possibility for cure from pulmonary metastases in soft tissue sarcoma; however, only 11% of the 19% of patients with an extremity sarcoma whose first distant recurrence is in the lung will be alive at 3 years, despite therapy. Complete resection and the development of more effective adjuvant treatments are imperative to improve outcome for this group of patients.

US$29.90

PMID: 8257219


Other references

Lee, S.J.; Lee, W.Y., 1991: A study on the vessel structure of Fagaceae species in Korea. (I). Appearance and variation of vessel volume and dimension. Thirteen species (9 Quercus spp., Fagus crenata, 2 Castanea spp., and Castanopsis cuspidata) were studied.

Gleghorn, L.; Ramesar, R.; Beighton, P.; Wallis, G., 2005: A mutation in the variable repeat region of the aggrecan gene (AGC1) causes a form of spondyloepiphyseal dysplasia associated with severe, premature osteoarthritis. Spondyloepiphyseal dysplasia (SED) encompasses a heterogeneous group of disorders characterized by shortening of the trunk and limbs. The autosomal dominant SED type Kimberley (SEDK) is associated with premature degenerative arthropathy and has be...

Aboujaoude, A.; Ussegliopolatera, J.M.; Vandevelde, T., 1997: System for the management of agricultural pollution: Eurekaismap project. Industrial and public partners from Italy, France and the UK, involved at various levels in the problems posed by agricultural pollution (water suppliers, chemical manufacturers, environmental administrations, farmers, research institutes, Informa...

Fibach, E.; Hasegawa, S.; Schechter, A.N.; Noguchi, C.T.; Rodgers, G.P., 1995: The two-phase liquid culture of human erythroid progenitors Application for studying sickling of erythroblasts from patients with sickle cell anemia. Beuzard, Y , Lubin, B , Rosa, J [INSERM Colloquium; Sickle cell disease and thalassaemias: New trends in therapy] Colloque INSERM; Sickle cell disease and thalassaemias: New trends in therapy 217-218

Harland, B.C.; Collings, D.A.; McNaughton, N.; Abraham, W.C.; Dalrymple-Alford, J.C., 2015: Anterior thalamic lesions reduce spine density in both hippocampal CA1 and retrosplenial cortex, but enrichment rescues CA1 spines only. Injury to the anterior thalamic nuclei (ATN) may affect both hippocampus and retrosplenial cortex thus explaining some parallels between diencephalic and medial temporal lobe amnesias. We found that standard-housed rats with ATN lesions, compared...

Duclos, P., 1976: Measurement of oral muscular forces exerted on the vestibular and lingual surfaces of the incisors. L' Orthodontie Francaise 47(0): 115-128

Anonymous, 2011: PDZK1 Regulation of NaPi-2c Transporter. The sodium-dependent phosphate (Na/Pi) transporters NaPi-2a and NaPi-2c play a major role in the renal reabsorption of Pi. The functional need for several transporters accomplishing the same role is still not clear. However, the fact that these tr...

Wilson, T.; Temple, N.J., 2004: Beverages in nutrition and health. This volume belongs to the Nutrition and Health series of books. It discusses how different beverages impact basic nutrition and risk of disease. It also helps explain the potential value of these beverages for the promotion of optimal human healt...

Che, N.Ying.; Huang, S.Jun.; Ma, Y.; Han, Y.; Liu, Z.Chen.; Zhang, C.; Mu, J.; Zhao, D.; Qu, Y.; Zhang, H.Qing.; Liu, Z.Dong.; Xu, S.Fa., 2017: Comparison of Histological, Microbiological, and Molecular Methods in Diagnosis of Patients with TBLN Having Different Anti-TB Treatment Background. The influence of anti-tuberculosis (TB) treatment history on tuberculous lymphadenitis (TBLN) diagnosis is unclear. Therefore, this study aims to evaluate the diagnostic methods, including histology, microbiology, and molecular tests, used for TBL...

Tadmor, C.T.; Galinsky, A.D.; Maddux, W.W., 2013: Getting the most out of living abroad: biculturalism and integrative complexity as key drivers of creative and professional success. The current research investigated how patterns of home and host cultural identification can explain which individuals who have lived abroad achieve the greatest creative and professional success. We hypothesized that individuals who identified wit...