+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Differential distribution of inositol 1,4,5-triphosphate receptors in the rat olfactory bulb

, : Differential distribution of inositol 1,4,5-triphosphate receptors in the rat olfactory bulb. Journal of Comparative Neurology 389(2): 224-234

The inositol 1,4,5-triphosphate receptor (IP3R) regulates the release of calcium from intracellular stores. In the present study, the distribution of IP3R in the rat main olfactory bulb was determined by immunohistochemistry. Immunofluorescence was used to double label for IP3R and for gamma-aminobutyric acid (GABA) or for projection neurons, which were retrogradely labeled following dextran injection into the lateral olfactory tract (LOT). The expression profile of IP3R changes dramatically during development. In the glomerular layer of adults, many juxtaglomerular neurons are IP3R immunoreactive [IP3R(+)]; the majority of these cells are also GABA immunoreactive [GABA(+)]. Scattered sparsely throughout the external plexiform layer are small numbers of IP3R(+) neurons, a small number of which are LOT-projecting tufted cells. Significant numbers of IP3R(+) neurons are in the granule cell layer; however, most of these cells are GABA(-). The vast majority of mitral cells contain little or no IP3R immunoreactivity. These findings indicate that, in the olfactory bulb of adult rats, IP3R is preferentially localized in specific classes of intrinsic neurons and that it is rarely expressed in projection neurons. In contrast, during the first postnatal week, the receptor is detected almost exclusively in mitral cells. Expression of IP3R in subclasses of intrinsic neurons begins during the second and third weeks, concomitant with a decrease in immunostaining of mitral cells. Adult patterns of IP3R immunostaining are apparent by the fourth postnatal week. These observations raise the possibility that the expression of IP3R in specific classes of neurons during development is activity dependent.


PMID: 9416918

Other references

McCoy, R.S.; Choi, S.; Collins, G.; Ackerson, B.J.; Ackerson, C.J., 2013: Superatom paramagnetism enables gold nanocluster heating in applied radiofrequency fields. The Au102(pMBA)44 nanocluster becomes a superatom paramagnet after chemical oxidation. Solutions of paramagnetic Au102(pMBA)44 heat in an oscillating magnetic field component of an RF field, but not in the electric component. Combined, these exper...

White, G.C.; McMillan, C.W.; Blatt, P.M.; Roberts, H.R., 1982: Factor VIII inhibitors: a clinical overview. There is much evidence to indicate that inhibitors to Factor VIII in patients with classical hemophilia are the result of an immunological response to exposure to material (VIII:C or VIII:CAg) that is absent or present in reduced amounts in these...

Nowak Jan, 1936: Horizontale Verteilung der Oelvarietaeten der polnisch-karpatischen Oelprovinz; rozmieszezenie poziome odmian ropy w prowincji naftowej Karpat polskich. Regional distribution of varying grades of petroleum in the Polish Carpathians.

Inayatullah, C.; Abbas, A., 1990: Expert systems for the management of rice and sugarcane pests. The use of 'Pest-man', a computer based expert system which attempts to aid the user in using information for integrated pest management problem solving and decision making, is outlined. Currently data is available for pests of rice and...

Liu, P-Ching.; Kieckhefer, G.M.; Gau, B-Shya., 2013: A systematic review of the association between obesity and asthma in children. To provide a comprehensive integration of contemporary studies focusing on the relationship between obesity and asthma in paediatric populations.The simultaneous increase in asthma and obesity prevalence has been widely discussed over the past 20...

Ramires, E.N.; Fraguas, G.M., 2000: Tropical house gecko Hemidactylus mabouia predation on brown spiders Loxosceles intermedia. Brown spiders ( Loxosceles spp.) are venomous arachnids, successfully adapted to urban habitats in Brazil. Loxoscelism became a serious public health problem in Parana State, especially at the capital Curitiba, where the most abundant species is...

Haas Otto, 1941: A case of inversion of suture lines in Hysteroceras varicosum Sow. A specimen of Hysteroceras varicosum var. angolana n. var. from Hanha, Lobito bay, Angola, shows inversion of suture lines.

Berkenkamp, B.; Jesperson, G.D.; Bissett, J., 1989: Leaf mottle, a new disease of canarygrass caused by Septoria triseti. In 1987, S. triseti was identified as the causal organism of leaf mottle of Phalaris canariensis in Saskatchewan. Pathogenicity was confirmed. In 1988, leaf mottle was the most widespread and severe disease of P. canariensis in this state.

Mazer, C.; Greenberg, R., 1943: Low-dosage irradiation in the treatment of amenorrhea. Low-dosage irradiation was applied to the pituitary gland and the ovary of 92 women who experienced varying degrees of infrequent bleeding or no bleeding. Their ages varied from 17-36 yrs. The bleeding history and the response to therapy are given...

Fitzgerald, W.F.; Engstrom, D.R.; Mason, R.P.; Nater, E.A., 1998: The case for atmospheric mercury contamination in remote areas. Elevated levels of mercury in aquatic environments remote from industrial sources have been broadly attributed to long-range atmospheric transport and deposition of anthropogenic Hg. Evidence in support of this prevailing scientific view-global bi...