+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Diffusion-weighted magnetic resonance tomography in diagnosis of encephalitis disseminata

, : Diffusion-weighted magnetic resonance tomography in diagnosis of encephalitis disseminata. Der Radiologe 40(11): 1057-1063

Magnetic resonance (MR) imaging is one of the best methods in diagnosis of multiple sclerosis, particularly in disclosure of active demyelinating lesions. Aim of this study was to compare diffusion weighted imaging and contrast enhancement in the detection of active lesions. A MR study with a contrast enhanced T1-weighted pulse sequence with magnetization transfer presaturation and a diffusion weighted echoplanar pulse sequence (b = 1000 s/mm2) was performed in 17 patients (11 women, 6 men) with multiple sclerosis. 29 of 239 lesions showed an increased signal intensity in diffusion weighted imaging, 24 lesions a contrast enhancement, but only 16 lesions were visible in both pulse sequences. In patients with short clinical symptomatology significant more lesions could be detected with diffusion-weighted pulse sequence in comparison to patients with long standing symptomatology showing more lesions with contrast enhancement. Hence it is likely, that both pulse sequences detect different histopathologic changes. The early detection of demyelinating lesions in diffusion weighted imaging is attributed to the extracellular edema, however the contrast enhancement is caused by a blood brain barrier abnormality. It can be expected that diffusion weighted imaging will have a high impact on imaging of multiple sclerosis not only in therapeutic trials, but also in clinical routine.


PMID: 11147321

Other references

Ramesh Rao, K., 1983: Role of wood and plant anatomy in archaeological studies of prehistoric India. Wood and plant remains from various sites on the Indian sub-continent have been examined at Dehra Dun over the last 30-40 yr. Those discussed range from neolithic to early historical. In general, on this evidence, climate and vegetation seem to ha...

Hatic, S.O.; Berlet, G.C., 2011: Particulated juvenile articular cartilage graft (DeNovo NT Graft) for treatment of osteochondral lesions of the talus. Foot & Ankle Specialist 3(6): 361-364

Junien, C., 1991: Molecular genetics of heart diseases. A familial approach. Cardiovascular diseases are the result of the interaction of genetic and environmental factors and constitute a complex group of monogenic and, above all, polygenic pathologies. The possibility of localising the responsible genetic factors on the...

Mathan, K.K.; Durairaj, D.J., 1967: Phosphorus fixation in Niigiri soils. In 40 surface-soil samples, P fixation ranged from 0 to 100%, with a mean of 79.6%. The soil with lowest pH (4.2) had 100% P fixation. On passing from low to high rainfall areas, P occurred more as insoluble Al-phosphates than as soluble Ca-phosph...

Mcmartin D.A., 1968: Latent infection of chickens with mycoplasma gallisepticum letter antibody production. Veterinary Record 83(11): 280

Wang Jinfu.; L.Z.enfeng., 1988: Community structures of main vegetable pests in the suburban district of Hangzhou. Acta Ecologica Sinica, 81: 78-85

Wagstaff, G.F., 1982: A small dose of commonsense--communication, persuasion and physiotherapy. PhysioTherapy 68(10): 327-329

Gosney, J.; Heath, D.; Williams, D.; Rios-Dalenz, J., 1991: Morphological changes in the pituitary-adrenocortical axis in natives of La Paz. Increased activity of the hypothalamic-pituitary-adrenocortical axis is part of the response to the stress of initial exposure to hypoxia, but there is evidence to suggest that it persists after homeostatic stability has been regained and acclimat...

Leibowitz, J.O.; Avicenna, 1981: Ibn Sina in Hebrew. Korot 8(1-2): 3-8

Bornschein, H.; Krejci, F., 1952: Bioelectrical analysis of the function of the intra-aural musculature. Monatsschr Ohrenheilk 86: 221-229