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Direct carrier detection and prenatal diagnosis of Sicilian and Spanish (delta beta)zero-thalassemias


, : Direct carrier detection and prenatal diagnosis of Sicilian and Spanish (delta beta)zero-thalassemias. Molecular and Cellular Probes 7(2): 167-168

We describe a direct method for detection of the Spanish and Sicilian (delta beta)zero-thalassemias. This method is based on the use of the deletion-junction sequences to design specific PCR primers. It permits a rapid screening of heterozygotes in populations at risk and provides a useful tool for early prenatal diagnosis of these forms of thalassemia.

US$29.90

PMID: 8321255


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