geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of IGF-I on placental thromboxane and prostacyclin release in severe intrauterine growth retardation


, : Effect of IGF-I on placental thromboxane and prostacyclin release in severe intrauterine growth retardation. Journal of Maternal-Fetal Medicine 6(6): 341-350

Our recent findings that IGF-I inhibits placental thromboxane (TxB2) release (1, 2) and that prostanoid release from placentas or certain pregnancies complicated by intrauterine growth retardation (IUGR) is decreased [Sorem KA, Siler-Khodr TM, Placenta, 16:503-515, 1995] led us to investigate the effect of IGF-I on prostanoid release from placentas of IUGR pregnancies. The placental response of 6-keto-prostaglandin F1a (6-keto-PGF1a) and thromboxane (TxB2) to IGF-I in severe IUGR (n = 5) was compared with the response in normal pregnancies (n = 6). Placentas were perifused with medium containing IGF-I at doses of 0, 5.2, 10.4, 20.8, and 83.3 ng/ml. In three of the five IUGR placentas (responsive group), incubation with IGF-I resulted in an inhibition of TxB2, attaining significantly greater inhibition at a lower dose of IGF-I than the normal placental response. However, in two of the five IUGR placentas (non-responsive group), the TxB2 was insensitive to the normal inhibitory action of IGF-I. The baseline production of prostanoids from the IUGR placentas was not predictive of their response to IGF-I. Moreover, 6-keto-PGF1a was not inhibited in any of the placentas, IUGRs, or normals. However, the ratio for TxB2 over 6-keto-PGF1a basal production rate from the zero treatment time to the fifth hour was significantly less in the nonresponsive IUGR placentas than for the responsive IUGR placentas or for the normal placentas. Certain IUGR placentas demonstrated a significant suppression of TxB2 with IGF-I, whereas other IUGR placentas were insensitive to exogenous IGF-I. A decreased and unchanging ratio of TxB2/6-keto-PGF1a production rate was characteristic of the nonresponders.

US$19.90

PMID: 9438218

DOI: 10.1002/(SICI)1520-6661(199711/12)6:6<341::AID-MFM9>3.0.CO;2-O


Other references

Ogita, S.; Imanaka, M.; Takebayashi, T.; Nakai, Y.; Fukumasu, H.; Matsuo, S.; Matsumoto, M.; Tanaka, B.; Iwanaga, K., 1990: Significance of exercise and bed rest in pregnancy--study on the lying postures of gravidas during sleep (2). For the purpose of determining the most reasonable lying posture for pregnant women, we investigated the lying positions of both 247 non-pregnant women and 302 pregnant women during sleep. As for the rate of each position during the entire period...

Nomme, J.; Su, Y.; Konrad, M.; Lavie, A., 2013: Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. Asparaginases catalyze the hydrolysis of the amino acid asparagine to aspartate and ammonia. Bacterial asparaginases are used in cancer chemotherapy to deplete asparagine from the blood, because several hematological malignancies depend on extrace...

Iida, N.; Seo, Y.; Ishizu, T.; Nakajima, H.; Atsumi, A.; Yamamoto, M.; Machino-Ohtsuka, T.; Kawamura, R.; Enomoto, M.; Kawakami, Y.; Aonuma, K., 2012: Transmural compensation of myocardial deformation to preserve left ventricular ejection performance in chronic aortic regurgitation. In patients with chronic aortic regurgitation (AR), systolic wall stress and volume overload affects left ventricular (LV) systolic function and remodeling. The aim of this study was to assess transmural rearrangements of myocardial deformation to...

Takasugi, M.; Muta, E.; Yamada, K.; Arai, H., 2017: A new method to evaluate anti-allergic effect of food component by measuring leukotriene B 4 from a mouse mast cell line. Leukotrienes (LTs), chemical mediators produced by mast cells, play an important role in allergic symptoms such as food allergies and hay fever. We tried to construct an evaluation method for the anti-LTB<sub>4</sub> activity of chemic...

Page, A.J., 2016: Mimecan: A Newly Identified Adipokine and Regulator of Appetite. Ebiomedicine 2(11): 1584-1585

Fisman, S.; Sangster, J.; Steele, M.M.; Stewart, M.A.; Rae-Grant, N., 1996: Teaching child and adolescent psychiatry to family medicine trainees: a pilot experience. To develop learning objectives for teaching child psychiatry to family medicine trainees and to evaluate the best method of teaching these objectives. For this descriptive study, knowledge, attitude, and skill objectives were presented to trainees...

Gnisci, A.; Stefani, L.; Bottin, P.; Ohannessian, A.; Gamerre, M.; Agostini, A., 2015: Predictive value of hemoperitoneum for outcome of methotrexate treatment in ectopic pregnancy: an observational comparative study. To assess the predictive value of hemoperitoneum for the outcome of methotrexate (MTX) treatment of ectopic pregnancy (EP). This observational prospective single-center study included women presenting with EP treated with MTX from November 2007 to...

Maun, D.; Silverberg, D.; Steinhagen, R.M., 2006: Acute ischemic proctitis: report of four cases. Acute ischemic proctitis is an extremely rare clinical entity. It is mainly described in patients with significant atherosclerotic and cardiac risk factors who present with lower gastrointestinal symptoms in the setting of hemodynamic instability....

Van D.K.r L.D.; Rittenhouse P.A.; Iyer L.V.; Herbert G.B.; Bonadonna A.M.; O'connor P.A.; Bethea C.L., 1990: Chronic cocaine alters the neuroendocrine responses to serotonin 5 ht agonists. FASEB Journal 4(3): A594

Lee, J-Seob.; Cha, H.Do.; Shim, J-Hyung.; Jung, J.Woo.; Kim, J.Young.; Cho, D-Woo., 2012: Effect of pore architecture and stacking direction on mechanical properties of solid freeform fabrication-based scaffold for bone tissue engineering. Fabrication of a three-dimensional (3D) scaffold with increased mechanical strength may be an essential requirement for more advanced bone tissue engineering scaffolds. Various material- and chemical-based approaches have been explored to enhance...