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Effects of interleukin-2 on the isolated rat heart and the mechanism


, : Effects of interleukin-2 on the isolated rat heart and the mechanism. Shi Yan Sheng Wu Xue Bao 34(2): 121-125

The purpose of the present study was to explore the biological effects and mechanism of interleukin-2 (IL-2) on the isolated rat heart. The results showed that hrIL-2 increased the number of premature ventricular contraction, heart rate, left ventricular developed pressure, left ventricular end-diastolic pressure and coronary flow in the isolated perfused rat heart. Heat inactivated hrIL-2 had no effect on the heart. Pretreatment with ryanodine canceled the positive effects of hrIL-2 on left ventricular developed pressure, left ventricular end-diastolic pressure and coronary flow but had no effects on arrhythmogenesis and tachycardia by hrIL-2. Pretreatment with nifedipine or low extracellular calcium abolished the arrhythmogenic effect of hrIL-2 and attenuated partially the augment of heart rate, left ventricular developed pressure, left ventricular end-diastolic pressure and coronary flow. It suggests that the cardiac activity of hrIL-2 depended on the integrity of its spatial structure and transmembrane influx Ca2+ and intracellularly stored Ca2+ were involved in the cardiac activity of hrIL-2.

US$29.90

PMID: 12549104


Other references

Carlsten, A.; Wennberg, M.; Bergendal, L., 1996: The influence of Rx-to-OTC changes on drug sales. Experiences from Sweden 1980-1994. A descriptive study of national sales data from Sweden to find out the effect of over-the-counter (OTC) switches on total sales of a number of drugs. During the period 1980-94, 16 drugs were changed from prescription only (Rx) status to the Swedis...

Sansone, R.A.; Watts, D.A.; Wiederman, M.W., 2015: Pain catastrophizing and employment histories. Studies examining pain catastrophizing and employment have had mixed findings. No study of pain catastrophizing has examined its relationship to lifetime employment status in a general clinical population. To examine pain catastrophizing in relati...

Kerecki, B.; Stefanovic, L.; Zaric, L., 1998: Effects of herbicides on some maize inbred lines. Bulgarian Journal of Plant Physiology (Special Issue): 313

Rowe Nicholas P.; Jones Timothy P., 2000: Devonian charcoal. Plants preserved as fossil charcoal are identified from the late Famennian of central Germany. The fossils consist of small angular fragments with a dull black lustre, brittle fracture, high quality microstructural preservation and homogenised cel...

Choi H.O.; Bae S.H.; Park N.K.; Kim D.S.; Chun K.S., 1965: The newly introduced rice m cultivar norin no 17. Research Reports of the Office of Rural Development (Suweon) 8(1): 105-109

Fields, J.H.A.; Hochachka, P.W., 1976: Oyster citrate synthetase ec 4.1.3.7 control of carbon entry into the krebs cycle of a facultative anaerobe. Citrate synthase (EC 4.1.3.7) in adductor muscle of the oyster Crassostrea gigas occurred in relatively low specific activity, about 1.5 .mu.mol product formed/min per g wet wt of tissue. The enzyme activity was essentially independent of pH betwe...

Perkins D.L.; Greenblatt H.C., 1971: Culturing of chaenea vorax protozoa ciliophora gymnostomatida. American Zoologist 11(4): 692

Hoelzer, 1972: The regulation of temperature equilibrium of the child in the health resort. Zeitschrift fuer Physiotherapie 24(1): 15-19

Rauste Von Wright M.; Von Wright J., 1981: A longitudinal study of psycho somatic symptoms in healthy 11 18 year old girls and boys. In a longitudinal developmental study, 90 boys and girls participated in a psychological investigation and were medically examined when they were 11, 13, 15 and 18 yr old. Habitual somatic discomfort was assessed by means of a questionnaire. Frequ...

Miki Masako; Otofuji Yo ichiro, 1989: Paleomagnetic study on Miyako-Jima Island in the South Ryukyu Arc. Rock Magnetism and Paleogeophysics 16: 44-46