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Effects of tamoxifen, droloxifene and 17 beta-estradiol on Rauscher mouse leukemogenesis


, : Effects of tamoxifen, droloxifene and 17 beta-estradiol on Rauscher mouse leukemogenesis. Cancer Letters 82(1): 89-94

The effects of tamoxifen (TAM), its 3-hydroxy congener droloxifene (DROL) and 17 beta-estradiol were investigated on leukemogenesis induced in BALB/c mice by Rauscher murine leukemia virus (RLV). Multiple applications of each compound, in a dose-dependent manner, resulted in reduced virus titer in the serum, delayed onset of splenomegaly and significant prolongation of survival. Although 17 beta-estradiol proved most effective, prevention of disease was not achieved either by short- or long-term treatment with any of the drugs tested.

US$29.90

PMID: 8033074


Other references

Krakowski, A.J., 1965: Suppression Of Anxiety With Oxazepam In A Private Psychiatric Practice. Psychosomatics 6: 26-31

Peter, E.T.; Nicoloff, D.M.; Sosin, H.; Bernstein, E.F.; Wangensteen, O.H., 1962: Observations upon portal hemodynamics during vasopressin administration in dogs. The intra-venous administration of vasopressin at the rate of 0.01 pressor unit/kg/ min. caused a 67.8% decrease in epiploic flow, a 63.4% decrease in mesenteric flow, a 47.8% decrease in portal flow and a 49. 7% decrease in portal pressure. These...

Tanaka, J.; Uchimura, N.; Maeda, H.; Inou, S., 2002: Effects of sandalwood on sleep and biological rhythm. The sleep-promoting effect of sandalwood (from Santalum album) was investigated in 8 healthy adults (mean age: 21 years) for 8 successive days. Day 1 was designated as the adaptation night, days 2 and 3 as the baseline nights, days 4-6 as the expe...

Anonymous, 1989: The basic mechanisms of US farm policy. Part two: deficiency payments, certificates, and PIK and Roll. Part of a series of booklets intended as an introduction to the key concepts of US farm policy, this booklet concentrates on deficiency payments, certificates and the PIK and Roll marketing options. These concepts are defined, examples given of th...

Sperber, P., 1977: Criteria for well-controlled device and diagnostic product investigations. Medical Research Engineering 12(6): 4-9

Powills, S., 1986: Business works to cure disability problem. Hospitals 60(9): 64-5, 67

Pla Sentis, I., 1998: A soil water balance model for monitoring soil erosion processes and effects on steep lands in the tropics. Water erosion is the major threat to soil and water conservation in the steep lands of the tropics. Besides surface erosion on gentle to moderate slopes, mass movements are common on steep slopes. In addition to the negative effects on productivit...

Jaramillo, E., 1999: Tuberculosis and stigma: predictors of prejudice against people with tuberculosis. Tuberculosis is a main cause of mortality and morbidity in developing countries. Although diagnostic and curative means are well known, they are not always available and affordable. Also, the disease has a worldwide stigma, which adds to the suffe...

Wain, R.L., 1948: Recent advances in the study of fungicides and insecticides. The mode of action of Bordeaux mixture and other Cu fungicides is discussed. Chemical investigations showed that the exudates from fungus spores contained amino acids which are active in dissolving Cu from Bordeaux deposit. Expts. on the relative...

Culberson, J.L.; Kimmel, D.L., 1975: Primary afferent fiber distribution at brachial and lumbosacral spinal cord levels in the opossum (Didelphis marsupialis virigniana). This paper describes the spinal cord distribution of primary afferent fibers from forelimb and hindlimb in the North American opossum. Fibers entering the cord distribute to all ipsilateral laminae (I-IX) within their segment of entry, often have...