+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Evaluation of blood clearance rates and biodistribution of poly(2-oxazoline)-grafted liposomes

, : Evaluation of blood clearance rates and biodistribution of poly(2-oxazoline)-grafted liposomes. Journal of Pharmaceutical Sciences 85(2): 133-137

Two amphipatic polymers of the poly(2-oxazoline) family, poly(2-methyl-2-oxazoline) (PMOZ) and poly(2-ethyl-2-oxazoline) (PEOZ), were synthesized with the carboxylic group positioned at either the initiation or termination ends of the polymer chains. Distearoylphosphatidylethanolamine was covalently linked to the carboxyl groups of the polymers, resulting in conjugates which incorporate readily into liposomes. Systematic evaluation of plasma clearance kinetics and biodistribution of liposomes containing hydrogenated soy phosphatidylcholine, cholesterol, and 5 mol % the polymer-lipid conjugates in mice revealed the following. Both polymers, PMOZ and PEOZ, exhibited long plasma lifetimes and low hepatosplenic uptake. PMOZ was more effective at decreasing blood clearance rates than PEOZ. The best results, which were quantitatively comparable to the results obtained with the optimized preparations of methoxypolyethylene glycol(PEG)-2000-grafted liposomes, were obtained with formulations containing PMOZ of molecular weight 3260.


PMID: 8683436

DOI: 10.1021/js9504043

Other references

Feddes, J.J.R.; McQuitty, J.B.; Harrison, H.P., 1980: Grain drying with solar-heated air. The use of solar heat for grain drying is discussed. Buildings adjacent to grain drying facilities can be used to collect the solar heat which can be ducted to the driers. A mathematical model was used to predict the drying capacity of solar-heate...

Conte, A.; Ronca, G.; Petrini, M.; Mautone, G., 2003: Effect of lecithin on epicutaneous absorption of diclofenac epolamine. The epicutaneous application of nonsteroidal antiinflammatory drugs in localized rheumatic diseases results in a highly targeted antiinflammatory action and is associated with reduced systemic effects. The new diclofenac epolamine (DHEP) salt is m...

Jouve, A.; Corriol, J.; Velasque, P.; Benyamine, R.; Peytavi, G., 1957: Comparative study of epicardial and intramural leads in man and dog; synchronous epicardial recordings of the ventricules, anterior and posterior surface. Journal de Physiologie 49(1): 223-226

Comerford, M.J.; Mottram, S.L., 2001: Movement and stability dysfunction--contemporary developments. A good understanding of the control processes used to maintain stability in functional movements is essential for clinicians who attempt to treat or manage musculoskeletal pain problems. There is evidence of muscle dysfunction related to the contr...

Mckenna, D.D.; Zangerl, A.R.; Berenbaum, M.R., 2002: A native hymenopteran predator of Agonopterix alstroemeriana Lepidoptera Oecophoridae in east-central Illinois. Agonopterix alstroemeriana is a European oecophorid moth that defoliates poison hemlock (Conium maculatum), a noxious Eurasian weed extensively naturalized throughout temperate Australia, New Zealand, North America, and South America. Throughout w...

Törn, C.; Hillman, M.; Sanjeevi, C.B.; Landin-Olsson, M., 2006: Polymorphisms of TNF microsatellite marker a and HLA-DR-DQ in diabetes mellitus-a study in 609 Swedish subjects. We explored the importance of the genetic markers microsatellite TNFa, HLA-DR3-DQ2, and DR4-DQ8 in diabetes mellitus. The studied groups comprised autoimmune type 1 (n = 63), nonautoimmune type 1 (n = 35), latent autoimmune diabetes in adults (LAD...

Tonnis, W.; Konig, F., 1952: In memoriam Fritz Konig. Munchener Medizinische Wochenschrift 94(47): 2393-2394

Anonymous, 1987: Regina v. Salford Health Authority, Ex Parte Janaway, 12 February 1987. The applicant was a receptionist for a health centre who refused to type letters for physicians referring patients for abortions. She challenged her dismissal by the health centre, arguing that she was legally authorized to refuse to type abortion...

Hitchcock, C.H.; Crimes, A.A., 1985: Methodology for meat species identification: A review. This review covers methods available for the recognition of the species of animal whose meat is present in raw materials or meat products. Isolation of species-specific proteins is cumbersome; however, isoelettric focusing followed by recognition...

Nohmi, N.; Rezende, P.N.; Magela, G.; Lopes, J., 1966: Therapy with Ciba-32'644-Ba. Treatment of schistosomiasis mansoni. Revista Brasileira de Medicina 23(6): 435-440