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Evaluation of the usefulness of testing for p53 mutations in colorectal cancer surveillance for ulcerative colitis


, : Evaluation of the usefulness of testing for p53 mutations in colorectal cancer surveillance for ulcerative colitis. American Journal of Gastroenterology 94(2): 456-462

Objective: Immunohistochemical staining for p53 suppressor gene mutations is sensitive and, therefore, has potential for use as a complementary test for dysplasia to improve ulcerative colitis (UC) cancer surveillance program performance. Methods: A cohort of 95 patients with long standing pan-UC enrolled in a surveillance program was studied. Archival colonic biopsy specimens were stained for p53 mutations and clinical information was obtained from medical records. Results: The 37 patients who developed p53 mutations were significantly more likely to develop dysplasia or cancer (relative risk (RR) 4.53, 95% confidence interval (Cl) 2.16-9.48). The p53 mutations developed approximately 8 months before low grade dysplasia, 26 months before high grade dysplasia, and 38 months before cancer. Three of seven cancer patients with p53 mutations had Dukes' stage C or D, whereas only one of five cancer patients without p53 mutations had Dukes' C or D; all three patients who died from metast atic cancer had p53 mutations (three of 37 vs 0 of 58, p < 0.03). Folic acid supplementation had a small, significant protective effect for p53 mutations (RR 0.97, Cl 0.94-1.00). Conclusion: p53 Mutations 1) are associated with, and likely precede, dysplasia and cancer, 2) are associated with cancer-related mortality, and 3) may possibly be prevented by folic acid supplementation.

US$19.90

PMID: 10022646

DOI: 10.1111/j.1572-0241.1999.877_f.x


Other references

Bohrer V.L., 1978: A nonpalynological method of reconstructing vegetation on the heavily over grazed rio puerco valley of new mexico. New Mexico Academy Of Science Bulletin:

Northcross, A.L.; Hwang, N.; Balakrishnan, K.; Mehta, S., 2016: Assessing exposures to household air pollution in public health research and program evaluation. Exposure to smoke from the use of solid fuels and inefficient stoves for cooking and heating is responsible for approximately 4 million premature deaths yearly. As increasing investments are made to tackle this important public health issue, there...

Ohkura, K.; Lee, J.D.e; Shimizu, H.; Nakano, A.; Uzui, H.; Horikoshi, M.; Fujibayashi, Y.; Yonekura, Y.; Ueda, T., 2003: Mitochondrials complex I activity is reduced in latent adriamycin-induced cardiomyopathy of rat. We previously reported on the use of enzymatic analysis to impair fatty acid metabolism followed by reduced myocardial energy content, leading to severe heart failure in adriamycin (ADR)-treated rats. The aim of this study is to investigate whethe...

Englert P.; Herpers U.; Herr W., 1981: Preatmospheric size of Dhurmsala, ALHA 77003, and other meteorites; Mn-53 and Al-26 studies on core samples. Meteoritics 16(4): 311-312

Gardestrom, L.; Karlsson, B.; Naumann, B., 1959: Social psychological aspects of cerebral palsy care. Experiences with activities of cerebral palsy patients at Konprinsessan Lovisas Barnsjukhus, 1952-58. Svenska Lakartidningen 56: 3373-3377

Rivoal, J.C.; Briat, B.; Cammack, R.; Hall, D.O.; Rao, K.K.; Douglas, I.N.; Thomson, A.J., 1977: The low temperature magnetic circular dichroism spectra of iron sulfur proteins part 1 oxidized rubredoxin. Variable temperature magnetic circular dichroism spectra were measured on oxidized Clostridium pasteurianum rubredoxin. The presence of two 1-electron charge-transfer transitions, sulfur to ferric ion, in the region 15,000-28,000 cm-1 was indicate...

Hosokawa, T.; Kikuchi, Y.; Shimada, M.; Fukatsu, T., 2007: Symbiont acquisition alters behaviour of stinkbug nymphs. In parasitic associations, the evolutionary interest of a symbiont contradicts that of a host, which sometimes causes the phenomena so-called 'parasite manipulation' wherein symbiont infection alters host behaviour to facilitate its vert...

Ravi, K.S.; Mehta, V.; Arora, J.; Suri, R.K.; Rath, G., 2013: Clinico-embryological submission of an unilateral anomalous presentation of axillary artery. Descriptions of the variant arterial pattern of upper limb are not exceptional and are therefore frequently reported in anatomy archives. A noteworthy deviation from the usual branching pattern was observed unilaterally in a single cadaver. This u...

Kouwaki, M.; Wada, Y., 1998: Malonic, methylmalonic and ethylmalonic acid semialdehyde dehydrogenase deficiency. Ryoikibetsu Shokogun Shirizu: 238-240

Deutsch, A.; Bentin, S.; Katz, L., 1999: Semantic influence on processing gender agreement: evidence from Hebrew. In the present study we examined the influence of manipulating the animacy of the sentential subject on the size of the syntactic priming effect induced by violation of subject-predicate gender agreement in Hebrew. The agreement violation delayed...