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Experimental study on the effect of extremities ischemia reperfusion inducing anterior tibial compartment pressure

, : Experimental study on the effect of extremities ischemia reperfusion inducing anterior tibial compartment pressure. Zhonghua Wai Ke Za Zhi 35(10): 630-633

We observed the changes of compartment pressure after extremities were reperfused at different intervals of ischemia and its relationship with the changes of serum MDA and CPK content. The protective effect of mannite on extremities ischemia reperfusion was also studied. 18 New Zealand rabbits were separated into three groups: group A (ischemia 4 h); group B (ischemia 8 h); group C (ischemia 4 h). The rabbits of group A and B were intravenous injected with normal saline (NS), and group C was injected with 20% mannite. The changes of compartment pressure of serum MDA and CPK content and the histological changes of skeletal muscles in every group were noted at different times: preoperation; the beginning of ischemia; the end of ischemia and reperfusion for 4 h; 24 h; 72 h, respectively. The longer ischmia lasted, the more serious the tissue damage was. Reperfusion made tissue damaged further. After reperfusion for 24 h, the damage was the most serious. Meanwhile, the serum MDA and CPK content also reached the peak value. These changes were in accord with those of compartment pressure. On the other hand, the damage of mannite group was relatively mild. Extremity ischemia reperfusion would led to the increase of compartment pressure, then intensified the damage. The damage was the most serious at 24 h of reperfusion. Using mannite could reduce the tissue damage and compartment pressure. Mannite should be recommended as the first-selected drug for extremity ischemia reperfusion injury.


PMID: 10678058

Other references

Lichko A.E.; Ozeretskovskii S.D., 1980: Characteristics of the clinical picture and course of schizo affective psychoses in adolescents. The clinical follow-up study of 181 adolescent patients, suffering from so-called schizoaffective psychoses allowed 3 main variants to be singled out on the basis of the clinical symptoms and features of the disease course: in the 1st variant the...

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Houwing C.J.; Jaspars E.M.J., 1986: Coat protein blocks the in vitro transcription of the virion rna species of alfalfa mosaic virus. Febs Letters 209(2): 284-288

Lee, S-Wuk.; Mao, C.; Flynn, C.E.; Belcher, A.M., 2002: Ordering of quantum dots using genetically engineered viruses. A liquid crystal system was used for the fabrication of a highly ordered composite material from genetically engineered M13 bacteriophage and zinc sulfide (ZnS) nanocrystals. The bacteriophage, which formed the basis of the self-ordering system, w...

Fidurov Y.N.; Tsinkina G.K., 1980: Changes in the state of capillaries and temperature of the skin of hands in workers of the footwear industry under the effect of synthetic glue of ntb type. Capillary network and temperature sensitivity of the skin of hands in 50 workers with 5-10 yr record who had contact with a synthetic glue of NTB type were studied. Synthetic glue of NTB type changed the state of capillaries and decreased the temp...

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Ermolenkov, V.V.; Zhelentsov, I.I., 1970: Main and residual effect of herbicides on barley. In trials during 3 years with barley, application of 2-5 kg MCPB or 16 kg nitroalkylphenols/ha decreased the average weed population by 98 and 94.3%, respectively, and increased grain yields by 0.38-0.41 and 0.31-0.33 t/ha, respectively.

Drake, M.T.; Violin, J.D.; Whalen, E.J.; Wisler, J.W.; Shenoy, S.K.; Lefkowitz, R.J., 2007: beta-arrestin-biased agonism at the beta2-adrenergic receptor. Classically, the beta 2-adrenergic receptor (beta 2AR) and other members of the seven-transmembrane receptor (7TMR) superfamily activate G protein-dependent signaling pathways in response to ligand stimulus. It has recently been discovered, howeve...

Gordon, A.J.; Burns, P.A.; Glickman, B.W., 1988: N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation in a RecA strain of Escherichia coli. 274 N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced forward mutations in the lacI gene of an Escherichia coli RecA- strain were cloned and sequenced. Base substitutions accounted for 264 mutations and consisted of 261 G:C----A:T transitio...

Michalec, C.; Stastny, M.; Novakova, E., 1958: Investigations on paper chromatographic separation of serum lipoproteins. Serum, 0.03 ml., is chromatographed by the descending technique on a strip of Whatman No. 3 paper impregnated with a veronal-oxalate-citrate buffer of pH. 8. 5, with a mixture of the buffer and isopropanol as the mobile phase. After 3 hr. the chro...