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Exploring prokaryotic diversity in the genomic era


, : Exploring prokaryotic diversity in the genomic era. Genome Biology 3(2): Reviews0003-Reviews0003

Our understanding of prokaryote biology from study of pure cultures and genome sequencing has been limited by a pronounced sampling bias towards four bacterial phyla - Proteobacteria, Firmicutes, Actinobacteria and Bacteroidetes - out of 35 bacterial and 18 archaeal phylum-level lineages. This bias is beginning to be rectified by the use of phylogenetically directed isolation strategies and by directly accessing microbial genomes from environmental samples.

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PMID: 11864374


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