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Expression patterns of alpha-, beta- and gamma-catenin in pancreatic cancer: correlation with E-cadherin expression, pathological features and prognosis


, : Expression patterns of alpha-, beta- and gamma-catenin in pancreatic cancer: correlation with E-cadherin expression, pathological features and prognosis. Anticancer Research 21(6a): 4127-4134

The E-cadherin-catenin cell adhesion complex has been implicated in tumour invasion and metastasis. In this study, we evaluated the clinical significance of E-cadherin and catenin expression in pancreatic cancer. The immunohistochemical expression and cellular co-localization of alpha-, beta- and gamma-catenin were investigated in 43 paraffin-embedded specimens of pancreatic cancer. The relationship between their expression and E-cadherin expression, clinicopathological features and prognosis was evaluated. Abnormal alpha-, beta- and gamma-catenin expression was found in 37%, 44% and 40% of cases, respectively. Both alpha-catenin and gamma-catenin expression correlated with disease stage and with lymph node and distant metastases, whereas aberrant beta-catenin expression only correlated with the presence of lymph node metastases. There was a significant and progressive concordance between E-cadherin and alpha-, beta- and gamma-catenin expression patterns, respectively. The expressions of alpha-, beta- and gamma-catenin also significantly correlated with one another. All three catenins, like E-cadherin, were associated with a poor prognosis, but only E-cadherin and alpha-catenin were independent prognostic factors for cancer-specific survival. Changes in catenin expression and pancreatic cancer progression are possibly related events. The expression of E-cadherin and alpha-catenin may add useful new prognostic information.

US$29.90

PMID: 11911306


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