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Fatal inhalational isopropyl alcohol poisoning in a neonate


, : Fatal inhalational isopropyl alcohol poisoning in a neonate. Journal of Toxicology. Clinical Toxicology 31(3): 473-481

A 37 weeks gestation, 1500 gram male infant with multiple dysmorphic features underwent surgery for gastroschisis several hours after birth. During post-operative mechanical ventilation, 70% isopropyl alcohol was accidentally placed in the humidifier of the ventilator, resulting in an estimated 2 h exposure. While the baby seemed clinically stable, initial neurological examination was confounded by recent sedation and pancuronium paralysis. Initial post-operative hypotension was corrected with fluid administration and remained stable for the remainder of the clinical course. By 2 h post-exposure, he was moving, breathing spontaneously and opening his eyes. Isopropyl alcohol and acetone levels at 1, 6, 10 h post exposure were 31/10, 22/15, 15/20 mmol/L respectively. Isopropyl alcohol elimination t1/2 was 9.6 h. Dialysis or exchange transfusion were considered but due to their high risk and the stable infant condition, it was elected to continue with supportive care only. 12.5 h post-exposure, he suddenly became cyanotic, bradycardic, then asystolic. Resuscitation efforts were unsuccessful. To our knowledge, this is the youngest patient reported to have toxic inhalational exposure to isopropyl alcohol and the first report on isopropyl alcohol pharmacokinetics at this age.

US$29.90

PMID: 8355323


Other references

Murnane R.J.; Stallard R.F., 1990: Germanium and silicon in rivers of the orinoco venezuela drainage basin. Nature (London) 344(6268): 749-752

Nickerson, T.A., 1960: An explanation for reduced incidence of sandiness. (Abstr. pap. read at ann. meeting Amer. Dairy Sci. Ass., June 1960). Only 5 of 36 commercial samples of ice cream became sandy during storage at 12 degrees F for 6 months. In experimental samples it was shown that vegetable gum stabilizers were the main reason for the low incidence of sandiness rather than emulsifi...

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Boris S.K.umgalz; Gerta Fainshtein; Lev Gorfunkel; Yaacov Nathan, 1990: Fluorite in Recent sediments as a trap of trace metal contaminants in an estuarine environment. The trace metal contamination of estuarine sediments of the Kishon river, running through a large industrial zone of Israel, was studied. The sediments were analysed for trace metal (copper, cadmium, iron, lead, mercury and zinc) contents, organic...

Anonymous, 1988: The celebration of society. Perspectives on contemporary cultural performance. Celebration in contemporary societies is the focus of the investigation. As celebration is built on paradoxical ambiguity, its vitality in the modern world constitutes a paradox. The celebrant takes 'time out' from practical affairs and...

Vaczy H.S., 1983: To what extent should we use the results of the duffy system in paternity serology. Forensic Science International 23(1): 68

Bu, X.J.; Liu, L.; Wang, L.; Nie, L.W., 2011: Isolation and characterization of 21 novel polymorphic microsatellite loci in the Chinese soft-shelled turtle Pelodiscus sinensis. Twenty-one novel polymorphic microsatellite loci were isolated from the Chinese soft-shelled turtle, Pelodiscus sinensis (Trionychidae). This is a commonly consumed Asian species, especially in China, where it is reared in large numbers on farms....

Sadusk, J.F.; Nesche, G., 1957: Reactions following use of influenza vaccine (Asian strain) in adults. Modern Hospital 89(5): 88 Passim-88 Passim

Scott T.M.; Glover R.B., 2000: Monitoring at Ngawha Springs before and after commissioning of the power station. Pre-commissioning monitoring of surface features at Ngawha from 1996 to 1998 generally supports the findings of Sheppard and Johnston (1984) in terms of temperature, mass flow rates of chemical species in solution, and gas species discharged. Alth...

Martin, C.; Fabre, J., 1985: Bronchopneumopathies as a result of inhalation of gastric contents. Cahiers D'anesthesiologie 33(7): 607-613