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From amyloid proteins to amyloidosis


, : From amyloid proteins to amyloidosis. La Revue du Praticien 47(16): 1761-1766

Amyloidosis, from a molecular point of view, is an extracellular deposition mainly constituted of low molecular mass proteins which are very rich in beta-pleated sheet structures. These proteins polymerase and self-assemble into insoluble fibrils which are resistant to proteases. Biochemically, the different forms of amyloidosis are classified according to the protein which is quantitatively the most important in the amyloid deposit. Most of the time it results from the proteolytic degradation of a plasma protein. This main protein is associated with a series of compounds, mainly of proteic nature, that are regularly found in all amyloid deposits.

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PMID: 9453199


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