geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Functional assay for HER-2/neu demonstrates active signalling in a minority of HER-2/neu-overexpressing invasive human breast tumours


, : Functional assay for HER-2/neu demonstrates active signalling in a minority of HER-2/neu-overexpressing invasive human breast tumours. British Journal of Cancer 74(5): 802-806

Overexpression of HER-2/neu in human breast carcinomas correlates with poor prognosis, although its strength as a prognostic indicator varies widely in different reports. Variability may be due to active signalling by HER-2/neu in a subset of the tumours in which it is overexpressed. To study this hypothesis, we have developed an activation state-specific anti-HER-2/neu monoclonal antibody. In this report, we use this antibody to analyse the signalling status of HER-2/neu in a large series of invasive breast carcinomas. Overexpression of HER-2/neu was detected in 9% of 223 cases. Of the cases demonstrating overexpression, active signalling by HER-2/neu was detected in only 35%. The clinicopathological characteristics of these cases are described. This functional assay is predicted to improve the utility of HER-2/ neu as a prognostic indicator.

US$29.90

PMID: 8795585


Other references

Rameezan, B.A.R.; Zaliha, O., 2006: Functional status of acute stroke patients in University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia. Stroke is a leading cause of death and disability in most developed countries and developing nations. Majority of the stroke survivors are left with significant physical and cognitive impairments. In addition to the improved acute stroke care, the...

Billings, S.D.; Walsh, S.V.; Nusrat, A.; Fisher, C.; Weiss, S.W.; Folpe, A.L., 2003: Aberrant expression of tight junction proteins ZO-1, claudin-1 and occludin in synovial sarcoma An immunohistochemical study with ultrastructural correlation. Modern Pathology 16(1): 294A-295A, January

Lee, J-A.; Gao, F-Biao., 2008: Regulation of Abeta pathology by beclin 1: a protective role for autophagy?. The amyloid beta (A beta) peptide is thought to be a major culprit in Alzheimer disease (AD), and its production and degradation have been intensely investigated. Nevertheless, it remains largely unknown how A beta pathology is modulated by the a...

Smith, H., 2014: Registry of veterinary pathology. Journal of the American Veterinary Medical Association 109: 223-223

Rabassa, J.; Carlini, A.A., 2005: Quaternary paleontology and biostratigraphy of southern South America. Journal of South American Earth Sciences. October; 201-2: i-ii, 1-155

Sabourin, S.; Irwin, J., 2008: Prevalence of sufficient physical activity among parents attending a university. The benefits of regular physical activity are well documented. However, approximately half of all university students are insufficiently active, and no research to date exists on the activity behavior of university students who are also parents. U...

Summers, N.D., 1959: The amounts of the blood clotting factors VIII and IX in umbilical venous blood. Study of the umbilical venous blood of 12 newborn children showed that factor VIII was present in normal amounts, but that factor IX was depressed to about 15% of the level found in adults. Differences found in factor VIII levels were not statisti...

Muto, T.; Miyajima, A.; Bamba, M.; Hirota, T., 2014: Disruption of elastic lamellae in the aorta by D-penicillamine and its effect on vaso-regulation in rats. We assessed the effects of D-penicillamine (D-PA) on cross-linkages in elastin and vaso-regulatory function in rats. After administration of D-PA at a dose of 100 mg/kg/day for 7 weeks to adult and young rats, the thoracic aortas were isolated. Th...

Masuzaki, H.; Tanaka, T.; Ebihara, K.; Hosoda, K.; Nakao, K., 2009: Hypothalamic melanocortin signaling and leptin resistance--perspective of therapeutic application for obesity-diabetes syndrome. The adipocyte-derived hormone, leptin controls feeding behavior, augments fatty acid beta-oxidation in the skeletal muscle, attenuates insulin secretion but enhances whole body insulin sensitivity and glucose disposal, thereby serving as a promisi...

McHaffie, H., 1997: Larva of Autographa gamma (Linnaeus) (Lepidoptera: Noctuidae) feeding in the wild on Athyrium distentifolium. A larva of Autographa gamma was found feeding on Athyrium distentifolium in the field in Scotland on 18 August 1996.