+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

High serum cobalamin levels in the clinical setting--clinical associations and holo-transcobalamin changes

, : High serum cobalamin levels in the clinical setting--clinical associations and holo-transcobalamin changes. Clinical and Laboratory Haematology 23(6): 365-371

Whereas low cobalamin levels have been studied intensively, systematic information about high levels, especially in the clinical setting, is scarce. Therefore, a prospective comparison was done of 60 patients with high cobalamin levels and 75 with normal levels obtained by a hospital laboratory over a 2.5 month period. Associations with clinical disorders and laboratory test results were examined. Transcobalamin (TC) I and II were measured, especially the holoproteins (TC carrying circulating endogenous cobalamin) which were fractionated with microfine silica powder. High cobalamin levels (> 664 pmol/l; > 900 ng/l) occurred in 94 of 670 consecutive clinically requested assays (14%). The only independently significant associations with a high cobalamin level were renal failure among the clinical disorders (P=0.01), elevated serum creatinine (P=0.0001) and diminished albumin (P=0.0002) levels among laboratory tests. Both holo-TC I and holo-TC II levels were increased in renal failure (P=0.0001) but the increase was relatively greater in holo-TC II. The results indicate that high cobalamin levels are more frequent than low ones in clinical practice and appear to be associated often with renal failure. The elevation of both holo-TC II and holo-TC I suggests that several mechanisms are operative. The accumulation of holo-TC II suggests that cellular uptake of cobalamin by the abundant TC II receptors in the kidney may be impaired. The much better known association of high cobalamin levels with leucocytic disorders is rare, and no association was seen with liver disease.


PMID: 11843883

Other references

Rebuck, J.W.; Monto, R.W.; Monaghan, E.A.; Riddle, J.M., 1958: Potentialities of the lymphocyte, with an additional reference to its dysfunction in Hodgkin's disease. The property possessed by lymphocytes to be formed heteroplastically from mesenchymatous elements (reticulum cells), as well as from other lymphocytes, has now been demonstrated experimentally by the transfer of lymphocyte-forming reticulum cells...

Dawson E.B.; Croft H.A.; Clark R.R.; Mcganity W.J., 1968: Study of seasonal variations in 9 cations of normal term placentas. American Journal of Obstetrics & Gynecology 102(3): 354-361

Ondiek, J.; Namukaya, Z.; Mtapuri-Zinyowera, S.; Balkan, S.; Elbireer, A.; Ushiro Lumb, I.; Kiyaga, C.; Goel, N.; Ritchie, A.; Ncube, P.; Omuomu, K.; Ndiege, K.; Kekitiinwa, A.; Mangwanya, D.; Fowler, M.Glenn.; Nadala, L.; Lee, H., 2017: Multi-country validation of SAMBA - A novel molecular point-of- care test for HIV-1 detection in resource-limited setting. Early diagnosis of HIV-1 infection and the prompt initiation of antiretroviral therapy are critical to achieving a reduction in the morbidity and mortality of infected infants. The SAMBA HIV-1 Qual Whole Blood Test was developed specifically for e...

Beninger, P., G.; Decottignies, P.; Guiheneuf, F.; Barille, L.; Rince, Y., 2007: Comparison of particle processing by two introduced suspension feeders: selection in Crepidula fornicata and Crassostrea gigas. In order to understand the trophic interactions between 2 introduced suspension feeders in Europe, the North American slipper limpet Crepidula fornicata (Gastropoda) and the Pacific oyster Crassostrea gigas (Bivalvia), it is first necessary to det...

Heinrichs, K., 2000: Prevention. Vaccination fatigue and scepticism in Germany. Reasons, background and possibilities of intervention. Kinderkrankenschwester 19(8): 328-332

Gupta, R.; Mahapatra, A.K.; Bhatia, R., 1995: Serial transcranial Doppler study in meningitis. Serieal transcranial doppler studies were carried out in 12 patients, who developed meningitis during their hospital stay. Blood flow velocities in large basal vessels of the anterior circle of Willis were correlated with CSF pleocytosis and CSF s...

Jahn A., 1986: Fourth international conference on permafrost. Biuletyn Peryglacjalny 31: 119-121

Ohminami, K.; Matsuoka, E.; Takahashi, Y.; Shimizu, D.; Okuda, H., 1984: Effect of mazindol on obesity induced by administration of gold thioglucose. The present experiments were carried out to elucidate the effect of mazindol feeding on obese mice made by gold-thioglucose injection. Mazindol was added to the diet at the level of 0.5, 2, 10 mg/kg body weight. It was found that oral administrati...

Hakim, M.; Lovering, R.M.; D.D.yne, P.G., 2003: Neutrophils are associated with a faster recovery after muscle injury. Medicine & Science in Sports & Exercise 35(5 Supplement): S239, May

Agarwal, N.; Yadav, V.S.; Kritsky, D.C., 2001: On Ancyrocephalus etropli Gussev, 1963, from Etroplus suratensis in India, with proposal of Sclerocleidoides gen n. The monotypic genus Sclerocleidoides gen. n. (Monogenoidea: Dactylogyridae) is proposed, and Ancyrocephalus etropli Gussev, 1963, is redescribed and transferred to Sclerocleidoides as its type species. Presence of a dextral vaginal sclerite appare...