+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Highperformance liquid chromatographic assay for lomefloxacin in plasma and its pharmacokinetics in healthy volunteers

, : Highperformance liquid chromatographic assay for lomefloxacin in plasma and its pharmacokinetics in healthy volunteers. Yao Xue Xue Bao 28(4): 286-289

A sensitive and simplified high performance liquid chromatographic procedure has been developed for quantification of lomefloxacin in human plasma. The recovery of lomefloxacin was 95 to 102%. The relative standard deviation was 2.1 to 7.8%. The calibration curve was linear in the range from 0.125 micrograms/ml to 5.012 micrograms/ml with r = 0.9998. The detection limit of the method is 25 ng/ml. The plasma drug concentration-time course after medication conformed to a 1-compartment open model with a first order absorption. Mean t1/2 value was 5.5 h.


PMID: 8213172

Other references

Xu, Y.; Shi, F.-ming., 2004: Scanning electron microscopy of maxillary and labial palpus sensilla of Rammeacris kiangsu (Tsai). Xinan Nongye Daxue Xuebao. Apr; 262: 151-154

Garrity, R.D., 1975: Studies on the fine structure, and selected uptake and digestive processes of the gut of Cotylaspis insignis Leidy, 1857 (Treamtoda: Aspidobothria). In the intestine of Cotylaspis insignis, cells in the anterior-most region contain an array of organelles normally associated with protein synthesis. The luminal portion of more posterior cells often appears to be sloughing off. Acid phosphatase w...

Verdecchia P.; Gatteschi C.; Benemio G.; Boldrini F.; Guerrieri M.; Porcellati C., 1989: Nocturnal blood pressure reduction and cardiac hypertrophy in hypertensives. Journal of Hypertension 7(SUPPL 6): S403

Yuan ZhiFa; Zhou JingYu; Guo ManCai; Wang XiaoLong, 2002: Gene diversity and Shannon information entropy. Evolution is irreversible and entropy is an inherent characteristic of this process. The Hardy-Weinberg law of equilibrium is based on the Shannon information entropy maximum principle. Species evaluation increases the population entropy. The equi...

Turpeinen, M.; Tolonen, A.; Uusitalo, J.; Jalonen, J.; Pelkonen, O.; Laine, K., 2005: Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation. Our objective was to study the effect of the antiplatelet agents clopidogrel and ticlopidine on bupropion (INN, amfebutamone) hydroxylation, a probe reaction for cytochrome P450 (CYP) 2B6 activity. Twelve healthy male volunteers took a single 150-...

Sinha, S.; Kumar, M., 2010: Pregnancy and chronic hepatitis B virus infection. The combination of chronic hepatitis B virus (HBV) infection and pregnancy presents unique management questions. Aspects of care that need to be considered include effects of hepatitis B on pregnancy, effects of pregnancy itself on the course of h...

Lin-Marq, N.; Clarkson, S.G., 1995: A yeast RNA binding protein that resembles the human autoantigen La. The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjögren's syndrome patients. A key property of this protein is its association with the U-rich termini of newly synthesized RNA...

Hefferren, J.J.; Kingman, A.; Stookey, G.K.; Lehnhoff, R.; Muller, T., 1984: An international collaborative study of laboratory methods for assessing abrasivity to dentin. An international collaborative study was conducted in which 1 surface profile and 2 radiotracer methods for assessing abrasivity of dentifrices on human dentin were compared. The study consisted of 2 phases: an open phase in which participating la...

Wang, K.; Kinoshita, M., 2013: Geophysics. Dangers of being thin and weak. Science 342(6163): 1178-1180

Zhang, C.; Boa-Amponsem, O.; Cole, G.J., 2017: Comparison of molecular marker expression in early zebrafish brain development following chronic ethanol or morpholino treatment. This study was undertaken to ascertain whether defined markers of early zebrafish brain development are affected by chronic ethanol exposure or morpholino knockdown of agrin, sonic hedgehog, retinoic acid, and fibroblast growth factors, four signa...