+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunocytochemical analysis of the inflammatory infiltrate in inclusion body myositis and other neuromuscular disorders with rimmed vacuoles

, : Immunocytochemical analysis of the inflammatory infiltrate in inclusion body myositis and other neuromuscular disorders with rimmed vacuoles. Arquivos de Neuro-Psiquiatria 56(3a): 388-397

Among 1400 muscle biopsies, we found 16 cases with rimmed vacuoles whose diagnosis were sporadic inclusion body myositis (IBM) (4 cases), juvenile spinal muscular atrophy (6 cases), distal myopathies (3 cases), limb-girdle muscular dystrophy (2 cases), and peripheral neuropathy (1 case). Monoclonal antibodies reactive for T lymphocytes and subsets, B lymphocytes, macrophages, natural killer cells, immunoglobulins, and complement were used to analyze the inflammatory infiltrate. The analysis was quantitative and according to the site of accumulation (interstitial, endomysial, and perivascular). The immunocytochemical analysis showed CD8+ lymphocytes in the interstitial in most cases, occasionally inside of muscle fibers, and rarely in the perivascular region. The IBM cases had an increased number of CD8+ lymphocytes comparing with the other diseases. CD8+/CD4+ ratio was increased in IBM compared with the other diseases. Macrophages were frequent in IBM, distal myopathy, and one case of limb-girdle muscular dystrophy. Natural killer cells were frequent at interstitial.


PMID: 9754419

Other references

Buss, A.R., 1979: Methdological issues in life-span developmental psychology from a dialectical perspective. In the last few years there have been several studies reported in the literature using bifactorial ANOVA designs for the description and/or explanation of developmental phenomena. As formulated by Schaie and Baltes, these bifactorial ANOVA designs...

Anonymous, 1988: Report of the Second Public Health Service AIDS Prevention and Control Conference. Public Health Reports 103 Suppl 1: 1-109

Chittenden, R.J.; Tur Rill, W.B., 1926: Taxonomic and genetical notes on some species of Nemophila. By the application of genetics to the problems of systematics the authors venture to improve the classification of the genus Nemophila proposed by Brand in Das Pflanzenreich. Brand's species, N. maculata Benth., N. aurita Lindl., and N. menzi...

Taschner, P.; König, W.; Andreas, M.; Trinius, W., 1976: Requirements for radiation protection in the use of stomatological radiodiagnostic installations. Stomatologie der Ddr 26(3): 184-190

Szenes, Mrs, E., 1974: The formation and development of the sugar industry in the -Soviet Union. Cukoripar 27 (5) 164-167

Barton, G.M.; Beers, C.; deRoos, P.; Eastman, S.R.; Gomez, M.E.; Forbush, K.A.; Rudensky, A.Y., 2002: Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes. If T cells require specific interactions with MHC-bound peptides during positive selection, then the specificities of T cells selected by one peptide should be distinct from those selected by another. We have examined positive selection of CD4 T c...

Farley J.R.; Baylink D.J., 1982: Purification of a skeletal growth factor from human bone. A skeletal growth factor was isolated and purified from demineralized human bone matrix. A dose of 6 .mu.g/ml of the purified factor significantly increased the proliferation rate of embryonic chick bone cells in serum-free culture (292% of contro...

Vassiliades, T.A.; Douglas, J.S.; Morris, D.C.; Block, P.C.; Ghazzal, Z.; Rab, S.Tanveer.; Cates, C.U., 2006: Integrated coronary revascularization with drug-eluting stents: immediate and seven-month outcome. We sought to demonstrate the safety and feasibility of an integrated coronary revascularization strategy that combines minimally invasive left internal thoracic artery to left anterior descending coronary artery anastomosis with drug-eluting stent...

Hammond, L.; Street, J.; Downing, J.; Pepperall, J.; Darke, C., 2006: A new HLA-B*5501 variant--B*550104. Tissue Antigens 68(2): 182-183

Faber, J.E.; Harris, P.D.; Wiegman, D.L., 1982: Anesthetic depression of microcirculation, central hemodynamics, and respiration in decerebrate rats. The objectives of this study were the development of a skeletal muscle microcirculatory preparation, in which the complications of drug anesthesia were minimized, and the quantitation of the effects of urethan and chloralose anesthesia on the micr...