+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Impact of a selenium chemoprevention clinical trial on hospital admissions of HIV-infected participants

, : Impact of a selenium chemoprevention clinical trial on hospital admissions of HIV-infected participants. HIV Clinical Trials 3(6): 483-491

To evaluate the impact of selenium chemoprevention (200 microg/day) on hospitalizations in HIV-positive individuals. Data were obtained from 186 HIV+ men and women participating in a randomized, double-blind, placebo-controlled selenium clinical trial (1998-2000). Supplements were dispensed monthly, and clinical evaluations were conducted every 6 months. Inpatient hospitalizations, hospitalization costs, and rates of hospitalization were determined 2 years before and during the trial. At enrollment, no significant differences in CD4 cell counts or viral burden were observed between the two study arms. Fewer placebo-treated participants were using antiretrovirals (p <.05). The total number of hospitalizations declined from 157 before the trial to 103 during the 2 year study. A marked decrease in total admission rates (RR = 0.38; p =.002) and percent of hospitalizations due to infection/100 patients for those receiving selenium was observed (p =.01). As a result, the cost for hospitalization decreased 58% in the selenium group, compared to a 30% decrease in the placebo group (p =.001). In the final analyses, selenium therapy continued to be a significant independent factor associated with lower risk of hospitalization (p =.001). Selenium supplementation appears to be a beneficial adjuvant treatment to decrease hospitalizations as well as the cost of caring for HIV-1-infected patients.


PMID: 12501132

DOI: 10.1310/A7LC-7C9V-EWKF-2Y0H

Other references

Wagle, V.G.; Villemure, J.G.; Melanson, D.; Ethier, R.; Bertrand, G.; Feindel, W., 1987: Diagnostic potential of magnetic resonance in cases of foramen magnum meningiomas. Meningioma is a histologically benign tumor that is second in frequency only to gliomas among primary intracranial tumors. Its extracerebral development and generally clear demarcation from the brain does not make it easier to detect on magnetic r...

Jacobs, K.W.; Falgoust, L., 1984: Psychometric properties of King's Rodent Emotionality Rating Scale. King's (1958) Rodent Emotionality Rating Scale has been used extensively as a measure of the effects of such experimental procedures as septal lesions. The Kind scale is apparently appropriate for a variety of applications in laboratory activ...

Rankin A.H.; Greenwood J.; Hargreaves D., 2003: Chemical fingerprinting of some East African gem rubies by laser ablation ICP-MS. Laser Ablation ICP-MS is a suitable method for determining the trace element chemistry of gem rubies because of its sensitivity (ppm levels) and high spatial resolution (less than 100 mu m (super 3) ). The method is best described as Quasi non-des...

Maeda, M.; Ikeda, H.; Tsuji, A.; Murakami, S.; Ito, S.; Kamada, S., 1995: Development of new label enzyme for bioluminescent enzyme immunoassay. Analytical Letters 28(3): 383-394

Hashizume K.; Kobayashi M.; Miyaomoto T.; Yamauchi K., 1986: Dependence of the mitochondrial uptake of triiodothyronine in rat kidney on cytosolic triiodothyronine binding protein. The effect of cytosolic T3-binding protein (CTBP) on mitochondrial T3 uptake was investigated by using rat kidney tissue in vitro. [125I]T3 uptake into mitochondria was time dependent in the absence of CTBP. Addition of CTBP to the incubation medi...

Schell, H.D.; Carsteanu, M.; Nasta, A.; Cornoiu, I.; Gozia, O.; Bentia, T., 1976: The influence of mineral nutrition on the amount of tropane alkaloids in datura inoxia. The repartition of tropane alkaloids in different organs of D. inoxia was reported as a function of mineral nutrition and the time of plant harvesting. The highest amount of these alkaloids was found in roots, leaves and flowers harvested with you...

Woll,, W., 1970: Keeping-hygienic aspects with special reference to housing climate in large pig-production. Tierzucht 24 (12) 438-440

Freire, G.C.; Campagnari, J.C.; Nogueira,; Borrelli, M.; de Góes, G.M., 1981: Internal urethrotomy with cold knife under direct vision. Revista do Hospital das Clinicas 36(5): 198-201

Stiles, C.W., 1910: Report Of The International Commission On Zoological Nomenclature. Science 32(830): 764-767

Wiśniewski, W.; Gorta, T., 1966: Separation of berberine, hydrastine and hydrastinine from rhizomes of Hydrastis Canadensis and from the liquid extract. Acta Poloniae Pharmaceutica 23(5): 455-458