geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Importance in diagnosis of gastritis of detection by PCR of the cagA gene in Helicobacter pylori strains isolated from children


, : Importance in diagnosis of gastritis of detection by PCR of the cagA gene in Helicobacter pylori strains isolated from children. Journal of Clinical Microbiology 33(12): 3300-3303

The cagA gene has been detected by PCR and DNA hybridization in 45 Helicobacter pylori strains isolated from children. For each child, clinical symptoms, endoscopic aspect of the gastric mucosa, and histological gastritis were evaluated. Gene-positive strains were associated with hemorrhagic gastritis in 66.6% of the children, while gene-negative strains were associated with hemorrhagic gastritis in 11.2% of the children (P = 0.0001). In addition, 88.8% of gene-positive strains were associated with severe histological gastritis (scores of 3 and 4), and gene-negative strains were collected from the gastric mucosa with the same type of infiltration of neutrophils and lymphocytes in the lamina propia in 55.5% of the children. These differences were statistically significant (P = 0.017). Gene-positive strains were also isolated more frequently from children with vomiting (P = 0.04), while the absence of clinical signs was not significantly different in cagA gene-positive or -negative patients. All of these observations confirmed the role of this cagA gene as a marker of gastric inflammation in children. The detection of this gene might be helpful to determine the degree of inflammation of the gastric mucosa in the absence of abdominal symptoms. We might better understand the natural history of H. pylori infection if we studied the evolution of gastritis in children with regard to the cagA status of isolated strains.

US$29.90

PMID: 8586721


Other references

Hoare, RD.; Sturgeon, MT., 1985: The Pennsylvanian foraminifer Glyphostomella Cushman and Waters in the Appalachian Basin, USA. Congres International de Stratigraphie et de Geologie du Carbonifere Compte Rendu, 102: 319-326

Petrovic, A.P., 1975: Occurrence of lung disease in cattle in an export slaughter-house in Tanzania. The helminths found in a study of the lung diseases of local zebu and boran cattle in a Tanzanian slaughter-house were Dictyocaulus viviparus and Echinococcus granulosus.

Turutanova Ketova, A.I.; Anonymous, 1929: The first collection of the fern Stachypteris in the Jurassic of Turkestan. S. turkestanica* (p. 142); S. t. form elongata*(p. 143).

Aksay, E.; Major, G.; Goldman, M.S.; Baker, R.; Seung, H.Sebastian.; Tank, D.W., 2003: History dependence of rate covariation between neurons during persistent activity in an oculomotor integrator. Persistent firing in response to a brief stimulus is a neural correlate of short-term memory in a variety of systems. In the oculomotor neural integrator, persistent firing that encodes eye position is maintained in response to transient saccadic...

Khadkikar Aniruddha S.; Sant D.A., 1998: Group discussion on Drainage evolution of northwestern India with special reference to the lost Sarasvati. Journal of the Geological Society of India 51(4): 553-554

Whitton, L., 1964: The cytotaxonomic status of Vaccinium angustifolium Aiton in commercial blueberry fields of Maine. The tetraploid V. angustifolium is the predominant form throughout Maine. It is commonly associated with V. myrtilloides. Cross pollinations between V. angustifolium and V. myrtilloides resulted in a normal set. The majority of V. angustifolium cl...

Scott, A.A.; Head, D.R.; Thiel, K.; Chen, I.M.; Whitaker, M.H.; Willman, C.L., 1993: Identification and characterization of a previously unrecognized form of acute leukemia co-expressing myeloid and natural killer cell-associated antigens. Laboratory Investigation 68(1): 100A

Rizza R.; Service F.; Westland R.; Hall L.; Patton G.; Haymond M.; Clemens A.; Gerich J., 1979: Comparison of peripheral venous portal venous sub cutaneous and intra peritoneal routes for insulin delivery in diabetic dogs. Clinical Research 27(4): 660A

Hodge, W.R., 1925: Recent Advances in our Knowledge of Scarlet Fever. Canadian Medical Association Journal 15(1): 21-25

Oladipupo, S.S.; Hu, S.; Santeford, A.C.; Yao, J.; Kovalski, J.R.; Shohet, R.V.; Maslov, K.; Wang, L.V.; Arbeit, J.M., 2011: Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence. Neovascularization is a crucial component of tumor growth and ischemia. Although prior work primarily used disease models, delineation of neovascularization in the absence of disease can reveal intrinsic mechanisms of microvessel regulation amenab...