+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Induction of high grade astrocytoma (HGA) by protons: molecular mechanisms and RBE considerations

, : Induction of high grade astrocytoma (HGA) by protons: molecular mechanisms and RBE considerations. Advances in Space Research 14(10): 267-270

Protons of a specific energy, 55 MeV, have been found to induce primary high grade astrocytomas (HGA) in the Rhesus monkey (Macaca mulatta). Brain tumors of this type were not induced by protons of other energies (32-2,300 MeV). Induction of HGA has been identified in human patients who have had radiation therapy to the head. We believe that the induction of HGA in the monkey is a consequence of dose distribution, not some unique "toxic" property of protons. Comparison of the human experience with the monkey data indicates the RBE for induction of brain tumors to be about one. It is unlikely that protons cause an unusual change in oncogenic expression, as compared to conventional electromagnetic radiation.


PMID: 11539960

Other references

Heuvelink, A.E.; Valkenburgh, S.M.; Tilburg, J.J.H.C.; Van Heerwaarden, C.; Zwartkruis-Nahuis, J.T.M.;, E., 2007: Public farms: hygiene and zoonotic agents. In three successive years, we visited petting farms (n = 132), care farms (n = 9 1), and farmyard campsites (n = 84), respectively, and completed a standard questionnaire with the objective of determining the hygienic status of these farms and des...

Fang, H.S.; Yu.F.Y., 1960: Foot binding in Chinese women. Canadian Journal of Surgery. Journal Canadien de Chirurgie 3: 195-202

Hinze, H.F.; DeLeon, C.; Mitchell, W.C., 2000: Dentists at high risk for hearing loss: protection with custom earplugs. This article provides information on the effects of noise, especially to dentists. It gives information on how to protect one's hearing and furnishes a technique to fabricate custom earplugs.

Biraben, A.; Genton, P., 2000: Topiramate in clinical practice (part 1). Multicentric retrospective analysis of the efficacy of topiramate as add-on therapy according to the topographic form of focal epilepsy. Randomized, controlled studies of new antiepileptic drugs do not always highlight their best utilization in clinical practice. The authors gathered 361 cases of focal epilepsies treated with topiramate (TPM) as an add-on to other anti epileptic dr...

Bax, J.J.; Visser, F.C.; Cornel, J.H.; Van Lingen, A.; Fioretti, P.M.; Sloof, G.W.; Visser, C.A., 1999: The extent of viable tissue determines the magnitude of improvement of LVEF post-revascularization. Journal of Nuclear Medicine 40(5 SUPPL ): 47P, May

Reinthal, P.N.; Riseng, K.J.; Sparks, J.S., 2003: Water management issues in Madagascar: biodiversity, conservation, and deforestation. Unknown

Méndez, Lía.I.; Crais, E.R.; Castro, D.C.; Kainz, K., 2014: A culturally and linguistically responsive vocabulary approach for young Latino dual language learners. This study examined the role of the language of vocabulary instruction in promoting English vocabulary in preschool Latino dual language learners (DLLs). The authors compared the effectiveness of delivering a single evidence-informed vocabulary ap...

Makee, H.; Tlas, M.; Amer, S.; Abdulla, J., 2007: Effect of inherited sterility and Bacillus thuringiensis on mortality and reproduction of Phthorimaea opercullela Zeller (Lepidoptera : Gelechiidae). The effect of a commercial formulation of Bacillus thuringiensis (Dipelo 2X) upon F, progeny of irradiated and non-irradiated Phthorimaea operculella male parents was investigated. F, progeny of irradiated parents was more susceptible to R. thurin...

Jernigan, D.B.; Cetron, M.S.; Paul, S.M.; Jessop, A.; Spitalny, K.C.; Breiman, R.F., 1995: Laboratory-based surveillance for drug-resistant Streptococcus pneumoniae Assessment of laboratory methods and plan for implementation. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 35(0): 41

Wehmeyer, M.H.; Ingiliz, P.; Christensen, S.; Hueppe, D.; Lutz, T.; Simon, K.Georg.; Schewe, K.; Boesecke, C.; Baumgarten, A.; Busch, H.; Rockstroh, J.; Schmutz, G.; Kimhofer, T.; Berger, F.; Mauss, S.; Schulze Zur Wiesch, J., 2017: Real-world effectiveness of sofosbuvir-based treatment regimens for chronic hepatitis C genotype 3 infection: Results from the multicenter German hepatitis C cohort (GECCO-03). There are limited data regarding the real world effectiveness of direct acting antivirals (DAA) for the therapy of chronic genotype 3 hepatitis C virus (HCV) infection. All HCV genotype 3 infected patients from the German hepatitis C cohort (GECCO...