+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Influence of morning or evening administration on absorption of theophylline

, : Influence of morning or evening administration on absorption of theophylline. Zhonghua Yi Xue Za Zhi 63(2): 113-118

Bronchoconstriction during the night causing nocturnal and early morning wheezing is recognized as a major problem for asthmatics. Oral sustained-release theophyllines (SRTs) were developed to reduce the symptoms. A circadian variation in theophylline kinetics has been demonstrated with many SRTs. The purpose of this study was to evaluate the differences in serum theophylline concentration (STC) caused by morning or evening dosing of Euphyllin Retard, a brand of SRT, for a period of 36 hours following oral administration. A total of nine non-smoking healthy male volunteers were involved in the study, with a two-period crossover comparison. They were randomly divided into two groups. The first group took a single oral dose of 350 mg Euphyllin Retard at 8:00 A.M. and the second group took it at 8:00 P.M. Blood samples were collected during the 36 hours following administration. Two weeks later, the first group took the drug at night and the second group took it in the morning. The difference in the absorption of theophylline with daytime administration versus night-time administration was assessed using pharmacokinetic parameters derived from the plasma drug concentration vs time curve. The means of unextrapolated area under the concentration vs time curve (AUC) from time 0 to 24 hours (AUCUN) and of the extrapolated AUC from time 0 to infinity (AUCEX) in the night phase were higher than those in the day phase (62.403 micrograms/ml/hr vs 53.081 micrograms/ml/hr, p = 0.9186; 107.21 micrograms/ml/hr vs 98.879 micrograms/ml/hr, p = 0.8807, respectively). The mean of maximum concentration (Cmax) was higher in the night phase than that in the day phase (4.166 micrograms/dl vs 3.451 micrograms/dl, p = 0.9234). Daytime administration showed a delayed time to maximum concentration (Tmax) when compared to that of night-time administration (6.5 hr vs 5.75 hr, p = 0.6244). The terminal elimination rate constant (Kel) was lower in the day phase than in the night phase (0.053 l/hr vs 0.06 l/hr, p = 0.7601). The day phase and night phase data are combined data from the two night and two day groups. The statistical analysis of the results show that the time of administration does not influence the STC. No diurnal variation in theophylline kinetics was found with Euphyllin Retard. This study was performed in a limited number of normal healthy subjects, and the same result is yet to be proved in asthmatic patients and a larger population of normal subjects.


PMID: 10677921

Other references

Galloro, V.; Rizzo, R., 1960: Analogies and diversity of pharmacological action on the cardiovascular system of ATP and DPN. Il Progresso Medico 16: 44-57

Chowdhury, A.; Santra, A.; Chaudhuri, S.; Ghosh, A.; Banerjee, P.; Mazumder, D.N., 1999: Prevalence of hepatitis B infection in the general population: a rural community based study. Available seroprevalence studies of hepatitis B in Indian population has limitations. A community based door to door epidemiological study was conducted between December 1997 and January 1988 to look for the dynamics of hepatitis B exposure in a s...

Bhattarai, A.; Joly, A.G.; Hess, W.P.; El-Khoury, P.Z., 2017: Visualizing Electric Fields at Au(111) Step Edges via Tip-Enhanced Raman Scattering. Tip-enhanced Raman scattering (TERS) can be used to image plasmon-enhanced local electric fields on the nanoscale. This is illustrated through ambient TERS measurements recorded using silver atomic force microscope tips coated with 4-mercaptobenzo...

Magalhães, Lélia.Cunha.; Darze, E.S.; Ximenes, Aônio.; Santana, O.; Bastos, J.; Guimarães, Aênio., 2004: Acute myocarditis secondary to pheochromocytoma. Arquivos Brasileiros de Cardiologia 83(4): 346-8; 343-5

Cheng, C-Ho., 2006: Boundary condition of polyelectrolyte adsorption. The modification of the boundary condition for polyelectrolyte adsorption on charged surface with short-ranged interaction is investigated under two regimes. For weakly charged Gaussian polymer in which the short-ranged attraction dominates, the b...

Hustmyer, F.G.; Schipani, E.; Peacock, M., 1993: BsmI polymorphism at the parathyroid hormone receptor locus (PTHR) in three populations. Human Molecular Genetics 2(8): 1330-1330

Rosenberg Georg, 1953: Das Profil des Rahnbauerkogels bei Grossreifling. Reports new data on the detailed stratigraphic and structural relations of the Triassic formations which form the Rahnbauerkogel near Grossreifling, in the Austrian Alps.

Lever, R.J.A.W., 1937: A preliminary Note on larval Parasites of the Spike Moth in Taveuni Islands. Of larvae of Timthaba trichogramma, Meyr. (coconut spike moth) collected in October 1937 from an estate on Taveuni (Fiji), 2.5, 0.8 and 41 per cent. were parasitized by Apanteles, Nemeritis and Erycia, respectively . Despite the percentage of para...

Keran, DC., 1976: Birds of prey mortality. Loon, 483: 122

Beck, C., 2001: Identification and assessment of effective services and interventions: the nursing home perspective. In the past decade, researchers across the world have published a great number of studies on the care of nursing home residents with dementia. Investigations have concentrated on such important subjects as special care units, staff training, funct...