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Insulin sensitivity in NIDDM patients with normo- and microalbuminuria

, : Insulin sensitivity in NIDDM patients with normo- and microalbuminuria. Wiadomosci Lekarskie 51(9-10): 435-440

There is contradictory information relating to insulin sensitivity in NIDDM patients with microalbuminuria. The numerous clinical and epidemiological investigations have revealed a greater insulin resistance in these patients. However on the ground of the Nielsen and co-workers observations it has been ascertained that the level of insulin sensitivity is similar in exactly selected NIDDM patients with normo- and microalbuminuria. It suggests, that the increased cardiovascular morbidity and mortality among microalbuminuric NIDDM patients may not primarily be a consequence of more pronounced levels of hyperinsulinemia or insulin resistance. The influence of environmental factors may aggravate resident insulin resistance, elevate albuminuria, and may cause itself an increased cardiovascular risk.


PMID: 9921108

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