geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Intracavitary ultrasound phased arrays for prostate thermal therapies: MRI compatibility and in vivo testing


, : Intracavitary ultrasound phased arrays for prostate thermal therapies: MRI compatibility and in vivo testing. Medical Physics 25(12): 2392-2399

A 62 element MRI-compatible linear phased array was designed and constructed to investigate the feasibility of using transrectal ultrasound for the thermal therapeutic treatment of prostate cancer and benign prostatic hyperplasia. An aperiodic design technique developed in a previous study was used in the design of this array, which resulted in reduced grating lobe levels by using an optimized random distribution of unequally sized elements. The element sizes used in this array were selected to be favorable for both grating lobe levels as determined by array aperiodicity and array efficiency as determined by width to thickness ratios. The heating capabilities and MRI compatibility of the array were tested with in vivo rabbit thigh muscle heating experiments using MRI temperature monitoring. The array produced therapeutic temperature elevations in vivo at depths of 3-6 cm and axial locations up to 3 cm off the central axis and increased the size of the heated volume with electronic scanning of a single focus. The ability of this array to be used for ultrasound surgery was demonstrated by creating necrosed tissue lesions in vivo using short high-power sonications. The ability of the array to be used for hyperthermia was demonstrated by inducing therapeutic temperature elevations for longer exposures. Based on the acoustic and heating performance of this array, it has the potential to be clinically useful for delivering thermal therapies to the prostate and other target volumes close to body cavities.

US$19.90

PMID: 9874833

DOI: 10.1118/1.598450


Other references

Scott, G.E.; Guthrie, W.D., 1966: Survival of European com borer larvae on resisfaat corn treated with nutritional substances. The following is substantially the authors' abstract. Studies were carried out in Iowa in 1965 on the assumption that the resistance of some varieties of maize to leaf feeding by Ostrinia nubilalis (Hb.) is caused at least partly by the absen...

Goyer, G.R.; Salvador, R.L.; Bolduc, R., 1968: Acetylenic phenolic bis-ethers with curarizing properties. I. Triethylammonium iodide series. Archives Internationales de Pharmacodynamie et de Therapie 171(1): 18-30

Jaffar, M.; Patterson, A.V.; Howe, N.J.; Stratford, I.J., 2000: MUP 98176 A novel cytotoxic indolequinone bioreductive delivery agent with enhanced hypoxic specificity. Journal of Pharmacy & Pharmacology 52(Supplement): 225, September

Marwan, A.Aziz.; Ngiu, C.Soon.; Periyasamy, P., 2013: An interesting finding in a patient with chronic diarrhoea. Annals of the Academy of Medicine, Singapore 42(2): 97-98

Takahashi, R., 1930: Some Aphididae from Nanking, China. Transactions of the Natural History Society of Formosa Taihoku, 20: 273-276

Dickey, J.R., 1984: Proposed grazing plan for Dinderesso Forest Reserve. This report outlines a range management plan for the Dinderesso Forest, Burkino Faso, aimed at benefitting wood production through prescribed burns and controlled grazing, while at the same time providing benefits to area herders through grazing r...

Heiss, J.A.; Breitling, L.P.; Lehne, B.; Kooner, J.S.; Chambers, J.C.; Brenner, H., 2016: Training a model for estimating leukocyte composition using whole-blood DNA methylation and cell counts as reference. Whole-blood DNA methylation depends on the underlying leukocyte composition and confounding hereby is a major concern in epigenome-wide association studies. Cell counts are often missing or may not be feasible. Computational approaches estimate le...

Herter, U., 1987: Effect of drying on corn seed quality. Only minor drying injury was found during the initial 4-24 h of drying when maize ears were harvested at 48 and 38% seed moisture and dried at 50 degrees C in a thin layer drying system. After this time period, germination dropped linearly with pr...

Webber, D.S.; Garcia, M.M.; Harlan, R.E., 1998: Distinct populations of neuronal nitric oxide synthase and somatostatin neurons in the dentate gyrus of the rat. Nitric Oxide 2(2): 132

Chibata, I.; Kakimoto, T.; Kato, J.; Shibatani, T.; Nishimura, N., 1967: Crystalline aspartic beta-decarboxylase of Pseudomonas dacunhae. Biochemical and Biophysical Research Communications 26(6): 662-667