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Is type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies

, : Is type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies. Diabetes Care 20(3): 438-445

Type II (non-insulin-dependent) diabetes may be associated with impaired cognitive function. A detailed search of the literature has identified 19 controlled studies in which cognitive function in type II diabetes has been examined. The studies vary widely with respect to the nature of the diabetic populations studied and the psychological tests used. Thirteen studies demonstrated that the diabetic individuals performed more poorly in at least one aspect of cognitive function. The most commonly affected cognitive ability was verbal memory. Psychomotor ability and frontal lobe function were affected less consistently. The remaining six studies showed no differences in cognitive ability between subjects with type II diabetes and nondiabetic control subjects, but none had adequate statistical power to detect a between-group difference in cognitive ability of 0.5 of a standard deviation (a medium effect size). These findings are consistent with type II diabetes being associated with an increased risk of cognitive dysfunction. However, the widespread differences in methodology between the studies should lead to a cautious interpretation of their conclusions. The etiology of any cognitive decrement in type II diabetes is likely to result from an interaction between metabolic abnormalities intrinsic to diabetes, diabetes-specific complications, and other diabetes-related disorders.


PMID: 9051402

Other references

Handwerger S.; Barry S.; Barrett J.; Markoff E.; Zeitler P.; Cwikel B.; Siegel M., 1981: Inhibition of synthesis and secretion of decidual prolactin by arachidonic acid. Human decidual explants exposed for 4 h to 150 .mu.M arachidonic acid synthesized and secreted 30.4% (P < 0.001) and 36.4% (P < 0.001) less 35S-PRL [prolactin], respectively, than control explants. Over a 5-h period, the inhibition of PRL se...

Gotoh Y.; Kobayashi M.; Sato M., 1976: Role of brain noradrenaline on amphetamine stereotypy effects of alpha methyl p tyrosine in particular. Japanese Journal of Pharmacology 26(SUPPL): 34P

Peterson, C.; Goldman, J.E., 1986: Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors. Aging and Alzheimer disease lead to alterations in several biochemical properties of cultured skin fibroblasts. Total bound calcium increases in fibroblasts due to normal aging (+52%) and is elevated even further with Alzheimer disease (+197%). Pr...

Spiegel, D.; Kraemer, H.C.; Bloom, J.R., 1998: A tale of two methods: randomization versus matching trials in clinical research. Psycho-Oncology 7(5): 371-375

Tsushima Konroku, 1969: Stratigraphy of the Kodomari-Kanita District, Aomori prefecture. Miocene-Pliocene succession in part of green tuff region, six formations, sedimentary and pyroclastic rocks, stratigraphic relations, molluscan faunas, correlative volcanic rocks, Japan.

Ekenze, S.O.; Okoro, P.E.; Amah, C.C.; Ezike, H.A.; Ikefuna, A.N., 2008: Typhoid ileal perforation: analysis of morbidity and mortality in 89 children. Typhoid ileal perforation is still prevalent in many developing countries. Despite the advances in the management, the outcome in children is still very poor. To determine the morbidity and mortality of childhood typhoid ileal perforation in a ter...

Enselme, J., 1959: Biochemical syndrome of dietary arteriosclerosis. Annales de la Nutrition et de L'alimentation 13: A637-A658

Corubolo, I.; Grims, M., 1955: Colorimetric determination of ergot alkaloids of Secale cornutum and its galenic preparations. Die Pharmazie 10(1): 60-61

Bou Ghanem, E.N.; Nelson, C.C.; D'Orazio, S.E.F., 2011: T cell-intrinsic factors contribute to the differential ability of CD8+ T cells to rapidly secrete IFN-γ in the absence of antigen. A subset of CD44(hi)CD8(+) T cells isolated from C57BL/6/J (B6) mice, but not BALB/c/By/J (BALB/c) mice, rapidly secrete IFN-γ within 16 h of infection with Listeria monocytogenes. This Ag-independent response requires the presence of both IL-12...

Kung, H.F.; Lee, C.W.; Zhuang, Z.P.; Kung, M.P.; Hou, C.; Plössl, K., 2001: Novel stilbenes as probes for amyloid plaques. Journal of the American Chemical Society 123(50): 12740-1