+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lyell syndrome and Stevens-Johnson syndrome caused by lamotrigine

, : Lyell syndrome and Stevens-Johnson syndrome caused by lamotrigine. Annales de Dermatologie et de Venereologie 126(1): 46-48

Lamotrigine is a new anticonvulsant belonging to the triazine family. Several cases of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been described in patients taking this drug. We report 2 cases in children attending the same hospital. Two children, aged 9 and 13 years, developed SJS and TEN respectively, 3 and 28 days after lamotrigine was added to their usual anticonvulsant regimen. In both cases, outcome was favorable despite major decline in psychomotor capacity in one. In the first case, chronological attributability was plausible for lamotrigine and doubtful for sodium valproate, clonazepam and hydrocortisone. In the second case, chronological attributability was probable for amoxicillin, plausible for lamotrigine and doubtful for sodium valproate, but the numerous previous absorptions of amoxicillin made lamotrigine more suspect. The risk of Steven-Johnson syndrome and toxic epidermal necrolysis is high with lamotrigine with an estimated frequency of 1/1000. This risk is probably higher than with other anticonvulsants. Associating lamotrigine with sodium valproate increases the frequency of adverse skin reactions.


PMID: 10095893

Other references

Costello, F.; Keane, M., T., 1992: Conceptual combination: A theoretical review. In the last decade, research on categorisation has been extended to deal with concept combination; the formation of complex concepts by combining two separate concepts (e.g., 'red apple', 'striped orange', 'fake gun')...

Dedek, M.; Svoboda, M., 1978: The dairy industry and the environment. This article discusses environmental problems in the Czechoslovak dairy industry, with particular regard to effluent reduction (and its economic aspects), air pollution and noise. Attention is drawn to the value of 'green areas' within d...

Gundlapalli, S.; Rathi, M.; Kohli, H.S.; Jha, V.; Sharma, A.; Minz, M.; Sakhuja, V., 2013: Efficacy of basiliximab induction in poorly matched living donor renal transplantation. Non-depleting antibody induction has the best safety profile in transplant recipients without an increased risk of infection or malignancy. This observational study was performed in intermediate immunologic risk live donor renal transplants to ass...

Hyde, R.R., 1914: Furtility and sterility in Drosophila ampelaphila. 2. Fertility in Drosophila and its behavior in heredity. Journal of Experimental Zoology Philadelphia, 17 173-212

Greiner, G.F., 1957: Research on sideropenia in pharyngo-esophageal paresthesia. Les Annales D'oto-Laryngologie 74(4-5): 278-285

Fernández-Fernández, S.; Bernabeu, A.M.; Rey, D.; Mucha, A.P.; Almeida, C.Marisa.R.; Bouchette, Fédéric., 2015: The effect of sand composition on the degradation of buried oil. The potential effects of the mineralogical composition of sediment on the degradation of oil buried on sandy beaches were investigated. Toward that purpose, a laboratory experiment was carried out with sandy sediment collected along NW Iberian Pen...

Mortimer, M.J.; Kay, J.; Jaron, A., 1992: Epidemiology of headache and childhood migraine in an urban general practice using Ad Hoc, Vahlquist and IHS criteria. In a survey conducted by a UK urban general practice, 98.1 per cent (1083) of the children registered aged three to 11 years took part in an interview. Possible migraine subjects took part in an extended interview, the results of which were record...

Hutchison, C.; Ganeev, R.A.; Witting, T.; Frank, F.; Okell, W.A.; Tisch, J.W.G.; Marangos, J.P., 2012: Stable generation of high-order harmonics of femtosecond laser radiation from laser produced plasma plumes at 1 kHz pulse repetition rate. We present a method for the creation of stable weakly ionized plasmas from laser ablation of solid targets using a 1 kHz pulse repetition rate laser, which can be used for stable high-order harmonic generation from plasma plumes. The plasma plumes...

Burton, R.A.; Tsurupa, G.; Medved, L., 2006: Identification of an Ordered Compact Structure within the Recombinant Bovine Fibrinogen aC-Domain Fragment by NMR. Biochemistry (American Chemical Society) 45(7): 57-66

Popov, V.V.; Shteinberg, D.M., 1958: Third Congress of the International Union for the Study of Social Insects. Entomol Obozrenie [Transl] 37(1): 179-182