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Management of adult immune thrombocytopenia


, : Management of adult immune thrombocytopenia. Reviews in Clinical and Experimental Hematology 5(3): 222-35; Discussion 311-2

Immune thrombocytopenia (ITP) is a heterogeneous disease with regard to pathogenesis, severity, spontaneous course and response to treatment. Except in patients with severe bleeding tendency and very low platelet counts (< 10 x 10(9)/L), there are no clear rules on the indications for treatment. The standard initial therapy is corticosteroids, but the optimal dose and duration of therapy is unknown and in practice, some patients may be overtreated by aiming for complete remission (CR). In patients who have no sustained response after steroids, the most effective single therapy is splenectomy. Laparascopic splenectomy has a very low mortality and moderate morbidity. Preoperative prediction of success is difficult. About 50% of patients are in CR or partial remission after 5 years, but there are few data on the long-term outcome. Patients who fail steroids and splenectomy are difficult to treat. The choice may be palliative, with low doses of steroids or aggressive therapy with the intention of sustained remission. In selected patients, high-dose immunoglobulin or anti-D may be useful to temporarily raise the platelet count. Other drugs tried in ITP had either no or very limited clinically meaningful efficacy.

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PMID: 11703816


Other references

Michael Peter J., 1985: Contrasting rare earth element differentiation trends in granites; control by trace phases. Abstracts with Programs - Geological Society of America 17(6): 369

Hearing, J.; Gething, M.J.; Sambrook, J., 1989: Addition of truncated oligosaccharides to influenza virus hemagglutinin results in its temperature-conditional cell-surface expression. In the preceding paper (Hearing, J., E. Hunter, L. Rodgers, M.-J. Gething, and J. Sambrook. 1989. J. Cell Biol. 108:339-353) we described the isolation and initial characterization of seven Chinese hamster ovary cell lines that are temperature con...

Chen Jianqiang; Wang Hongzhen, 1986: SEM study of the microskeletal structures of Gyalophylloides Cao, 1975. Earth Science Journal of China University of Geoscience

Plancherel, A.C.; Bonard, E.C., 1965: The use of Valium in internal medicine. Praxis 54(29): 878-881

Gonzalez, Mh, 1982: What type of grazing system for my ranch? Pastures. Sheep and goat handbook(3): 313-320

Fruhstorfer, H., 1923: Lycaenidae (part). Die Gross-schmetterlinge der Erde. Fauna Indo-Australica, 9: 897-901

Singer R.N.; Johnson P.J., 1987: Strategies to cope with pain associated with sport related injuries. Athletic Training 22(2): 100-103

Harris, Albert K., 1994: Multicellular mechanics in the creation of anatomical structures. NATO ASI (Advanced Science Institute) Series Series H Cell Biology, 84: 87-129

Siddiqi, S.H.; Hwangbo, C.C.; Silcox, V.; Good, R.C.; Snider, D.E.; Middlebrook, G., 1984: Rapid radiometric methods to detect and differentiate Mycobacterium tuberculosis/M. bovis from other mycobacterial species. The Bactec radiometric method for the detection and differentiation of mycobacteria was evaluated in a 3-phase study. In the first phase the morphology of the bacteria in ZN-stained smears, the rate of CO2 evolution radiometric tests for niacin pr...

Ishiguro, N.; Hirohara, D.; Hotta, M.; Takano, K.; Kawashima, M., 2001: Linear erythema craquelé due to acute oedema in anorexia nervosa. British Journal of Dermatology 145(2): 357-359